{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:07:48Z","timestamp":1784185668591,"version":"3.55.0"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    This study aimed to demonstrate in vitro and in silico antimicrobial efficacy of the fixed oil derived from the seeds of\n                    <jats:italic>Sanguisorba minor<\/jats:italic>\n                    Scop., a plant traditionally utilized for wound healing, burn treatment, and hemorrhage control. As a result of GC\u2013MS analysis, 14 distinct saturated and unsaturated fatty acids, predominantly linoleic acid (\n                    <jats:bold>11<\/jats:bold>\n                    , 43.25%), \u03b1\u2010linoleic acid (\n                    <jats:bold>12<\/jats:bold>\n                    , 25.33%), and oleic acid (\n                    <jats:bold>10<\/jats:bold>\n                    , 20.73%) were determined. The DPPH\u2022 and ABTS\n                    <jats:sup>+<\/jats:sup>\n                    radical scavenging effects of the oil were determined to be of low\u2010middle activity. As a result of antibacterial and antifungal activities, MIC values against tested Gram\u2010positive and Gram\u2010negative species ranged between 1.406 and 11.25\u2009\u00b5L\/mL. While the MBC values of plant fixed oil for bacterial species ranged between 22.5 and 45\u2009\u00b5L\/mL, this value varied between 5.625 and 11.25\u2009\u00b5L\/mL for\n                    <jats:italic>Candida<\/jats:italic>\n                    species. Molecular docking studies revealed that the antifungal and antimicrobial activities of our ligands are expected to occur at micromolar levels. In particular, the antimicrobial activity of the fixed oil was demonstrated by the higher docking scores and inhibitory effects at lower concentrations of oleic acid (\n                    <jats:bold>10<\/jats:bold>\n                    ), linoleic acid (\n                    <jats:bold>11<\/jats:bold>\n                    ), and \u03b1\u2010linolenic acid (\n                    <jats:bold>12<\/jats:bold>\n                    ), which specifically played a role in this process.\n                  <\/jats:p>","DOI":"10.1002\/open.70250","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:32:24Z","timestamp":1783056744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Antimicrobial Activities of Fixed Oil From\n                    <i>Sanguisorba minor<\/i>\n                    Seeds by In Vitro and In Silico Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2779-6160","authenticated-orcid":false,"given":"Zehra","family":"Torun","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Inonu University, Faculty of Pharmacy  Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-2716","authenticated-orcid":false,"given":"Tuba","family":"Unver","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology Inonu University, Faculty of Pharmacy  Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-8557","authenticated-orcid":false,"given":"Harun","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry F\u0131rat University, Faculty of Pharmacy  Elaz\u0131g Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunyamin","family":"Goktas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry F\u0131rat University, Faculty of Pharmacy  Elaz\u0131g Turkiye"},{"name":"Department of Pharmaceutical Chemistry Anadolu University, Graduate Education Institute  Eskisehir Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3820"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115595980"},{"key":"e_1_2_10_4_1","volume-title":"Bioactive Components and Biochemical Properties in Foods","author":"Y\u0131lmaz M. 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