{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:26:02Z","timestamp":1786940762196,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    This study aimed to valorize\n                    <jats:italic>Erica arborea<\/jats:italic>\n                    L. collected in Algeria by characterizing its chemical composition and assessing the biological potential of its organic extracts. The aerial nonflowering parts were extracted using solvents of increasing polarity, allowing evaluation of chemical and biological properties of extracts. Phytochemical assays revealed that the ethyl acetate (EtOAc) fraction contained the highest levels of total polyphenols (419.58\u2009\u00b1\u20091.89\u2009\u00b5g\u2009GAE\/mg), flavonoids (174.57\u2009\u00b1\u20091.93\u2009\u00b5g\u2009QE\/mg), and flavonols (61.64\u2009\u00b1\u20092.49\u2009\u00b5g\u2009QE\/mg). GC\u2013MS profiling confirmed the presence of several bioactive constituents, supporting its rich chemical composition. Antioxidant activity highlighted the superiority of EtOAc extract, with IC\n                    <jats:sub>50<\/jats:sub>\n                    of 5.07\u2009\u00b1\u20090.63\u2009\u03bcg\/mL in the ABTS\n                    <jats:sup>\u2022+<\/jats:sup>\n                    assay, 26.96\u2009\u00b1\u20091.16\u2009\u03bcg\/mL in the DPPH\n                    <jats:sup>\u2022<\/jats:sup>\n                    assay, and an A\n                    <jats:sub>0.5<\/jats:sub>\n                    of 18.14\u2009\u00b1\u20090.57\u2009\u03bcg\/mL in the FRAP test, while the phenanthroline assay showed strong reducing power across all extracts (\n                    <jats:italic>A<\/jats:italic>\n                    <jats:sub>0.5<\/jats:sub>\n                    \u2009=\u20091.25\u2009\u00b1\u20090.05\u20136.72\u2009\u00b1\u20090.15\u2009\u03bcg\/mL). Antimicrobial activity revealed that the EtOAc fraction exhibited notable activity against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (19.33\u2009\u00b1\u20090.57\u2009mm) and\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    (19.0\u2009\u00b1\u20091.0\u2009mm), while all fractions showed antifungal activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Fusarium oxysporum<\/jats:italic>\n                    . Molecular docking on xanthine oxidase and DNA gyrase (GyrA and GyrB) revealed favorable interactions of several metabolites, supporting the antioxidant and antibacterial activities observed experimentally.\n                  <\/jats:p>","DOI":"10.1002\/open.70271","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:53:37Z","timestamp":1785851617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Profiling and In\u2009Vitro Assessment of Antioxidant and Antimicrobial Properties of Algerian\n                    <i>Erica arborea<\/i>\n                    L. Extracts, Strengthened by Molecular Modeling Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-4489","authenticated-orcid":false,"given":"Amina","family":"Bramki","sequence":"first","affiliation":[{"name":"Higher National School of Biotechnology Taoufik Khaznadar  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-219X","authenticated-orcid":false,"given":"Ouided","family":"Benslama","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Engineering, Valorization, and Innovation of Agri\u2010Food Products University of Larbi Ben M\u2019hidi  Oum El Bouaghi Algeria"},{"name":"Research Unit of Environmental and Structural Molecular Chemistry University of Constantine (Mentouri)  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5739-5048","authenticated-orcid":false,"given":"Fatima Zohra","family":"Makhlouf","sequence":"additional","affiliation":[{"name":"Higher National School of Biotechnology Taoufik Khaznadar  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Andolfi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zineb","family":"Mokhbi","sequence":"additional","affiliation":[{"name":"Higher National School of Biotechnology Taoufik Khaznadar  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selsabile","family":"Nedjaoum","sequence":"additional","affiliation":[{"name":"Higher National School of Biotechnology Taoufik Khaznadar  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawki","family":"Bensouici","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-3065","authenticated-orcid":false,"given":"Maria Michela","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Production University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0609-8902","authenticated-orcid":false,"given":"Marco","family":"Masi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.03.053"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2023.103785"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.12991\/jrp.2018.113"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2013.03.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111843"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.24925\/turjaf.v11i4.830\u2010837.5698"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30122616"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2024.100697"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2014.895184"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1701200134"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113881"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13233425"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202502955"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5344\/ajev.1965.16.3.144"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.09.028"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2005.09.011"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142657"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12161\u2010011\u20109275\u20104"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0891\u20105849(98)00315\u20103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5264\/eiyogakuzashi.44.307"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2008.04.055"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142152"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00304948.2023.2178213"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15010065"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.55779\/nsb16211862"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26104754"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18101563"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2023.102247"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2021.2014970"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14062167"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2013.01.014"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2023.e01585"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2007.03.024"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.107011"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12020279"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3166\/phyto\u20102019\u20100210"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974\u2010360X.2025.00112"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.56042\/ijbb.v57i5.41171"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132531"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.10.122"},{"key":"e_1_2_9_42_1","first-page":"35","article-title":"Investigating the Synergistic Antioxidant Effects of Some Flavonoid and Phenolic Compounds","volume":"1","author":"Hajimehdipoor H.","year":"2014","journal-title":"Research Journal of Pharmacognosy"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065\u2010017\u20100323\u2010z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.202100249"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.775751"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.04.040"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.2739"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2023.102933"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010009\u20102355\u20103"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2016.03.001"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041114"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.08.028"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad037"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14030188"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.8.4449\u20104457.2004"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz494"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12088\u2010012\u20100313\u20108"},{"key":"e_1_2_9_58_1","first-page":"151","article-title":"Antifungal Activity of Ester Derivatives From Caffeic Acid Against Candida Species","volume":"7","author":"De Farias M. O.","year":"2016","journal-title":"International Journal of Pharmacy and Pharmaceutical Research"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2014.05.047"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14020200"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14472"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2021.108573"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000414"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01205\u201023"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.200800231"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02993"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.39.1.9.17"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30030749"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12039\u2010024\u201002264\u20108"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010370"}],"container-title":["ChemistryOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.70271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/open.70271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.70271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:11:34Z","timestamp":1786939894000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/open.70271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/open.70271"],"URL":"https:\/\/doi.org\/10.1002\/open.70271","archive":["Portico"],"relation":{},"ISSN":["2191-1363","2191-1363"],"issn-type":[{"value":"2191-1363","type":"print"},{"value":"2191-1363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70271"}}