{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:25:55Z","timestamp":1786940755141,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Fluorinated drugs are highly important, and one of their common structural motifs is the trifluoromethyl group. As a result, there is an increasing demand for new or improved synthetic pathways toward trifluoromethylated compounds. One such route, developed less than one and a half decades ago, is trifluoromethylation\u2010induced lactonization of unsaturated carboxylic acids. Initial successes (including the only known enantioselective protocol for this reaction) were achieved using Togni's reagent II in the presence of a Cu(I) catalyst (mechanism: radical trifluoromethylation, then Cu\u2010assisted lactonization), then the focus shifted to photocatalytic methods (mechanism: radical trifluoromethylation, single\u2010electron oxidation, then lactonization). Later, electrocatalytic methods were developed too (mechanism: radical trifluoromethylation, single\u2010electron oxidation, then lactonization). Recently, the first CF\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>+<\/jats:sup>\n                    transfer\u2010induced lactonization was finally realized as well. The purpose of this review is to provide a comprehensive overview of the current state of this field of research. First, the importance of trifluoromethylation, CF\n                    <jats:sub>3<\/jats:sub>\n                    \u2010containing drugs, and lactonizations is explained briefly. Then, possible reaction mechanisms of trifluoromethylation\u2010induced lactonizations are discussed. Finally, I will present known trifluoromethylative lactonizations, grouped according to their mechanisms and the type of chemistry involved.\n                  <\/jats:p>","DOI":"10.1002\/open.70273","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:47:04Z","timestamp":1785721624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trifluoromethylation\u2010Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-0197","authenticated-orcid":false,"given":"Attila M.","family":"Remete","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Chemistry University of Szeged  Szeged 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