{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:25:54Z","timestamp":1786940754468,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Ultrasmall cyclodextrin\u2010based nanogels (CDngs) crosslinked with ethylene glycol diglycidyl ether (EGDE) were tested as drug delivery systems for poorly water\u2010soluble anticancer agents for the first time. Two compounds with well\u2010established pharmacological activity but critical solubility limitations, i.e., Osthole and Combretastatin A\u20104 (CA\u20104), were selected to evaluate the encapsulation capacity and performance of the nanogel platform. After preliminary screening through experimental and docking investigation, CA\u20104 was chosen as the reference compound. Among the formulations developed, the CA\u20104\/loaded nanogel displayed the highest encapsulation efficiency (EE%). Despite a less\u2010than\u2010ideal host\u2013guest fit, the large cavity of \u03b3\u2010CD allows for efficient drug encapsulation and higher loading capacity. The optimized formulation was tested in vitro to assess both the biocompatibility of \u03b3\u2010CDngs, as well as the anticancer efficacy of CA\u20104 loaded \u03b3\u2010CD and \u03b3\u2010CDngs. We demonstrate that empty systems exhibit intrinsic biocompatibility, showing no cytotoxicity toward the A2780 cancer cell line under experimental conditions. Furthermore, the CA\u20104 loaded \u03b3\u2010CDngs retained and enhanced the cytotoxic properties of the free drug against this cell line, compared to the corresponding native \u03b3\u2010CD. Collectively, these findings validate CDngs as a promising and innovative platform for the delivery of hydrophobic anticancer molecules and support their potential for further therapeutic development.<\/jats:p>","DOI":"10.1002\/open.70274","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:35:01Z","timestamp":1785897301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasmall Cyclodextrin\u2010Based Nanogels as Drug Delivery Systems"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-0953","authenticated-orcid":false,"given":"Andrea","family":"Cesari","sequence":"first","affiliation":[{"name":"Department of Chemistry and industrial Chemistry University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Braccini","sequence":"additional","affiliation":[{"name":"Department of Chemistry 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