{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:05:11Z","timestamp":1789981511211,"version":"4.0.1"},"reference-count":76,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"publisher","award":["4789\/UN6.3.1\/PT\/.00\/2025"],"award-info":[{"award-number":["4789\/UN6.3.1\/PT\/.00\/2025"]}],"id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Gadolinium nanoparticles (GdNPs) have been studied extensively due to their lower toxicity and better magnetic resonance imaging (MRI) detection capabilities than Gd\u2010chelates. Their surfaces are conveniently modified with several molecules to enhance their accumulation in the cancer of interest, thereby enabling more accurate diagnosis and treatment. In this study, hydrothermal GdNPs were functionalized with folic acid (FA) (for active targeting), polyethylene glycol (to improve biocompatibility), and azide molecules (for subsequent click reaction) via a silane ligand exchange conjugation method. Results showed a hydrodynamic diameter of 7.90\u2009nm and a zeta potential of \u22126.80\u2009mV for Azide\u2010PEG\u2010Folate\u2010modified GdNPs. UV spectra confirmed the presence of FA in NPs at UV absorption of 284 and 353\u2009nm. Typical FTIR spectra also appeared at wavenumbers of 2950 and 2150\u2009cm\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    , confirming the presence of PEG and azide molecules on modified NPs, respectively. Additionally, modified NPs maintained good stability for up to 3 weeks at 25 and 4\u2009\u00b0C. A preliminary click in vitro investigation also showed the NPs\u2019 good viability even after incubation at 132 \u00b5g\/mL, followed by the click reaction with 300 \u00b5g\/mL of Holmium(III)\u2010complexed\u2010DOTA\u2010BCN on HeLa cancer cells. This first click\u2010combination finding serves as a promising candidate for Gd\/Ho\u2010MRI agents, thereby enabling a more accurate diagnosis due to their simultaneous T\n                    <jats:sub>1<\/jats:sub>\n                    \/T\n                    <jats:sub>2<\/jats:sub>\n                    contrast enhancement.\n                  <\/jats:p>","DOI":"10.1002\/open.70276","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:35:59Z","timestamp":1787031359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Azide\u2010PEG\u2010Folate Functionalized Gadolinium Nanoparticles: A Preliminary Click\u2010Chemistry Platform for Magnetic Resonance Imaging Contrast"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-9221","authenticated-orcid":false,"given":"Retna Putri","family":"Fauzia","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Padjadjaran  Sumedang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azmi Aulia","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Padjadjaran  Sumedang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Afriani","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Padjadjaran  Sumedang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresia Cicilia","family":"Magdalena","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Padjadjaran  Sumedang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy Florencia","family":"Sutanto","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Padjadjaran  Sumedang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galuh","family":"Yuliani","sequence":"additional","affiliation":[{"name":"Chemistry Study Program Universitas Pendidikan Indonesia  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-6541","authenticated-orcid":false,"given":"Angga Cipta","family":"Narsa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmacy Mulawarman University  Samarinda Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9825-4425","authenticated-orcid":false,"given":"Safri","family":"Ishmayana","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Padjadjaran  Sumedang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna Dini","family":"Haryuni","sequence":"additional","affiliation":[{"name":"Research Center for Radioisotopes, Radiopharmaceuticals, and Biodosimetry Technology Research Organization for Nuclear Energy \u2013 National Research and Innovation Agency KST BJ Habibie  Tangerang Selatan Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Henan Provincial People\u2019s Hospital &amp; the People\u2019s Hospital of Zhengzhou University  Zhengzhou P. 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