{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:04:19Z","timestamp":1789981459558,"version":"4.0.1"},"reference-count":177,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:italic>Salvia balansae<\/jats:italic>\n                    , an endemic Algerian species, remains poorly investigated despite the recognized medicinal importance of the\n                    <jats:italic>Salvia<\/jats:italic>\n                    genus. This study comprehensively evaluated its phytochemical composition, biological activities, and safety profile. Quantitative analyses revealed high levels of total phenolics, flavonoids, flavonols, condensed tannins, and triterpenoids, while LC\u2013MS identified a distinctive Aur\u00e8s\u2010region chemotype enriched in luteolin, rosmarinic acid, and flavonoid glycosides. The extract demonstrated strong antioxidant activity in free radical\u2010scavenging, metal\u2010chelating, and reducing\u2010power assays. Anti\u2010inflammatory activity was confirmed by inhibition of protein denaturation in vitro and significant suppression of croton oil\u2010induced ear edema and histopathological damage in vivo. Molecular docking predicted favorable binding of salvianolic acid, rutin, and apigenin\u20107\u2010O\u2010glucoside to NLRP3 inflammasome components, suggesting a potential mechanism underlying the observed anti\u2010inflammatory effects. The extract also exhibited moderate inhibitory activity against cholinesterases and \u03b1\u2010amylase, indicating possible neuroprotective and antidiabetic potential. Acute oral toxicity testing at 2000\u2009mg\/kg showed no mortality, major clinical signs of toxicity, or apparent organ damage, although repeated\u2010dose studies are warranted. Collectively, these findings identify\n                    <jats:italic>S. balansae<\/jats:italic>\n                    as a polyphenol\u2010 and triterpenoid\u2010rich species with considerable promise for pharmaceutical and nutraceutical applications.\n                  <\/jats:p>","DOI":"10.1002\/open.70280","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:42:35Z","timestamp":1787290955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Phytochemical, Antioxidant, and NLRP3\u2010Linked and Anti\u2010Inflammatory Evaluation of\n                    <i>Salvia balansae<\/i>\n                    (Aur\u00e8s Chemotype): Insights Into Its Safety and Therapeutic Potential"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2785-4949","authenticated-orcid":false,"given":"Khadra 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University of Abbes Laghrour  Khenchela Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-4642","authenticated-orcid":false,"given":"Chawki","family":"Bensuici","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Ali Mendjeli UV 03  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chikha","sequence":"additional","affiliation":[{"name":"Laboratory of Science and Techniques for Living Institute of Agricultural and Veterinary Sciences Mohamed Cherif Messaadia University  Souk Ahra Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Nagaz","sequence":"additional","affiliation":[{"name":"Drylands and Oases Cropping Laboratory IRA Medenine  Medenine Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-973X","authenticated-orcid":false,"given":"Ayomide 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