{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:04:19Z","timestamp":1789981459612,"version":"4.0.1"},"reference-count":115,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    The growing interest in natural product research as a safer and sustainable alternative to synthetic drugs has triggered this study, which evaluates the chemical profile and biological activity of\n                    <jats:italic>Orobanche racemosa<\/jats:italic>\n                    extracts. In the current study, extraction was performed from\n                    <jats:italic>O. racemosa<\/jats:italic>\n                    using the maceration method with several extraction solvents. The extracts were examined for their antioxidant and enzyme\u2010inhibitory activities and their effects on cell viability. In high\u2010performance liquid chromatography\u2013MS\/MS analysis, a total of 31 compounds was detected across all studied extracts. The EtOH and EtOH\/water extracts consistently exhibited the highest antioxidant capacities in almost all tested assays. Similarly, EtOH and EtOH\/water extracts showed vigorous anti\u2010AChE activity, measuring 2.88 and 2.35\u2009mg\/GALAE, respectively. In the cell viability assay, both EA and EtOH extracts of\n                    <jats:italic>O. racemosa<\/jats:italic>\n                    demonstrated potent cytotoxicity, significantly reducing viability in normal (HEK293) and cancer cell lines (HepG\n                    <jats:sub>2<\/jats:sub>\n                    , SH\u2010SY5Y), indicating high toxicity without selectivity. Molecular docking screened 384 theoretical compound\u2013target combinations and retained 251 unique complexes with docking scores of \u22127.0 kcal\/mol or lower after duplicated entries were removed. Subsequent single\u2010trajectory molecular dynamics analysis of seven representative high\u2010scoring complexes generated hypotheses regarding structural persistence under the simulated conditions; however, these computational predictions require experimental validation.\n                  <\/jats:p>","DOI":"10.1002\/open.70283","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:39:16Z","timestamp":1787031556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Chemical and Biological Assessment of\n                    <i>Orobanche racemosa<\/i>\n                    Extracts Using Chromatographic, In Vitro, In Silico, and Cell\u2010Based Techniques"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-4140","authenticated-orcid":false,"given":"Nilofar","family":"Nilofar","sequence":"first","affiliation":[{"name":"Department 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