{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:05:39Z","timestamp":1789981539355,"version":"4.0.1"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Chalcone\u2010sulfonamide hybrids (\n                    <jats:bold>12a\u2013h<\/jats:bold>\n                    ) were synthesized via Claisen\u2013Schmidt condensation in good yields (64%\u201383%) and confirmed by NMR spectroscopy. The compounds exhibited moderate to good antibacterial activity against Gram\u2010negative (\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ) and Gram\u2010positive (\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus pyogenes<\/jats:italic>\n                    ) bacteria, with inhibition zones of up to 14.7\u2009mm at 10\u2009mg\/mL, lower than that of sulfamethoxazole but comparable to that of related hybrids. DPPH antioxidant evaluation revealed IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.2\u201311.8\u2009\u03bcg\/mL, with compounds\n                    <jats:bold>12e<\/jats:bold>\n                    and\n                    <jats:bold>12c<\/jats:bold>\n                    exhibiting the highest activity. Additionally, compound\n                    <jats:bold>12e<\/jats:bold>\n                    had the strongest protein denaturation inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200929.89\u2009 \u00b5g\/mL), while\n                    <jats:bold>12g<\/jats:bold>\n                    and\n                    <jats:bold>12h<\/jats:bold>\n                    showed superior anti\u2010proteinase activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u2009115.6 and 112.2\u2009\u00b5g\/mL), outperforming diclofenac sodium. Molecular docking against DHPS (1AJ0, 1AD4), myeloperoxidase (1DNU), COX\u20102 (5IKR), and topoisomerase\n                    <jats:italic>II\u03b1<\/jats:italic>\n                    (4FM9) showed strong binding affinities (\u22128.3 to \u221210.3\u2009kcal\/mol), supported by key hydrogen\u2013bonding and hydrophobic interactions. SwissADME and ProTox\n                    <jats:italic>II<\/jats:italic>\n                    analyses indicate favorable drug\u2010like properties, including Lipinski compliance, high GI absorption, no BBB penetration, and low predicted toxicity (LD\n                    <jats:sub>50<\/jats:sub>\n                    \u2009&gt;\u20096000\u2009mg\/kg). The hybrids presented here represent promising multifunctional leads with antibacterial, antioxidant, anti\u2010inflammatory, and drug\u2010like properties.\n                  <\/jats:p>","DOI":"10.1002\/open.70292","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:22:01Z","timestamp":1787818921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Chalcone\u2010Sulfonamide Hybrids as Antibacterial, Antioxidant, and Anti\u2010Inflammatory Agents With Comprehensive In Silico and ADMET Profiling"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3049-6065","authenticated-orcid":false,"given":"Mlis","family":"Belete","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry College of Applied Natural Science Adama Science and Technology University  Adama Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-0934","authenticated-orcid":false,"given":"Endale","family":"Mulugeta","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry College of Applied Natural Science Adama Science and Technology University  Adama Ethiopia"},{"name":"Department of Chemistry College of Natural Sciences Kyungpook National University  Taegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rentsch","sequence":"additional","affiliation":[{"name":"Laboratory for Functional Polymers Empa, Swiss Federal Laboratories for Materials Science and Technology  D\u00fcbendorf Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhdin","family":"Aliye","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry College of Applied Natural Science Adama Science and Technology University  Adama Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kebede","family":"Shenkutie","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry College of Applied Natural Science Adama Science and Technology University  Adama Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadessa","family":"Melaku","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry College of Applied Natural Science Adama Science and Technology University  Adama Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/bjbs.2023.11387"},{"key":"e_1_2_9_3_1","first-page":"1139","article-title":"Synthesis and Evaluation of Sulfonamide\u2010Containing Chalcones for Antibacterial Activity","volume":"48","author":"Al_khafaji S. 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