{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:55:53Z","timestamp":1790668553404,"version":"4.1.0"},"reference-count":89,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    The genus\n                    <jats:italic>Salvia<\/jats:italic>\n                    , widely known as sage, represents the largest group within the Lamiaceae family and includes numerous species with traditional uses. This study investigates the chemical composition, antioxidant activity, enzyme inhibition, and antibacterial activity of the aerial parts and roots of two\n                    <jats:italic>Salvia<\/jats:italic>\n                    species,\n                    <jats:italic>Salvia heldreichiana,<\/jats:italic>\n                    and\n                    <jats:italic>Salvia tomentosa<\/jats:italic>\n                    . For chemical analysis, ultraperformance liquid chromatography\u2010quadrupole\u2010time\u2010of\u2010flight mass spectrometry (LC\u2013QTOF\u2013MS) was used. LC\u2013QTOF\u2013MS analysis revealed that the extracts from the aerial parts of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>tomentosa<\/jats:italic>\n                    had a higher number of metabolites than those of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>heldreichiana<\/jats:italic>\n                    , including amino and organic acids, various phenolic compounds, and unknown metabolites.\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>heldreichiana<\/jats:italic>\n                    aerial parts water extract possessed the highest antioxidant activity in CUPRAC\u2009&gt;\u2009FRAP &gt;\u2009ABTS\u2009&gt;\u2009DPPH\u2009&gt;\u2009MCA\u2009&gt;\u2009PBD. For the enzyme inhibition,\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>heldreichiana<\/jats:italic>\n                    root extracts exhibited the highest anti\u2010AChE activity, particularly in Ethanol extracts (2.88\u2009mg GALAE\/g), while the highest anti\u2010BChE activity was the ethanol extract of the aerial part (3.65\u2009mg\u2009GALAE\/g). Consequently, the ethanol\/water aerial part extracts, with their superior antioxidant, phenolic, and multienzyme inhibitory profile, present themselves as best candidates of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>heldreichiana<\/jats:italic>\n                    and\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>tomentosa<\/jats:italic>\n                    for further in vivo pharmacological evaluation and development.\n                  <\/jats:p>","DOI":"10.1002\/open.70302","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:09:39Z","timestamp":1790057379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Integrated Metabolomics and Bioactivity Approach to Characterize\n                    <i>Salvia heldreichiana<\/i>\n                    and\n                    <i>Salvia tomentosa<\/i>\n                    Extracts"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-6013","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"first","affiliation":[{"name":"Deparment of Biology Science Faculty Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-4140","authenticated-orcid":false,"given":"Nilofar","family":"Nilofar","sequence":"additional","affiliation":[{"name":"Deparment of Biology Science Faculty Selcuk University  Konya Turkey"},{"name":"Botanic Garden \u201cGiardino dei Semplici\u201d Department of Pharmacy  \u201cG. d'Annunzio\u201d University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Kalyniukova","sequence":"additional","affiliation":[{"name":"Faculty of Forestry and Wood Sciences Czech University of Life Sciences Prague  Praha, Suchdol Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasil","family":"Andruch","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Institute of Chemistry Faculty of Science P. J. \u0160af\u00e1rik University  Ko\u0161ice Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-9794","authenticated-orcid":false,"given":"Giancarlo Angeles","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology University of Perugia  Perugia Italy"},{"name":"Centro di Ricerca per l\u2019Innovazione, Digitalizzazione, Valorizzazione e Fruizione del Patrimonio Culturale e Ambientale (CE.D.I.PA.)  Spoleto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-1079","authenticated-orcid":false,"given":"Paola","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology University of Perugia  Perugia Italy"},{"name":"Centro di Ricerca per l\u2019Innovazione, Digitalizzazione, Valorizzazione e Fruizione del Patrimonio Culturale e Ambientale (CE.D.I.PA.)  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