{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:55:39Z","timestamp":1790924139198,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004935","name":"S\u00fcleyman Demirel \u00dcniversitesi","doi-asserted-by":"publisher","award":["TSG\u20102024\u20109516"],"award-info":[{"award-number":["TSG\u20102024\u20109516"]}],"id":[{"id":"10.13039\/501100004935","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    A set of newly developed 1,3\u2010selenazole\u20102\u2010amine derivatives (\n                    <jats:bold>1\u20134<\/jats:bold>\n                    ) was prepared via a modified Hantzsch\u2010type cyclization of appropriately substituted \u03b1\u2010bromoacetophenones with selenourea under reflux conditions. The synthesized compounds were tested for cytotoxic activity in HT\u201029 (colon cancer), MCF\u20107 (breast cancer), and L929 (mouse fibroblast) cell lines using the MTT assay. The compounds induced weak to moderate cytotoxicity in MCF\u20107 cells. Among them, compound\n                    <jats:bold>4<\/jats:bold>\n                    showed cytotoxic activity with IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 171.10\u2009\u00b5M, while no appreciable activity was observed against HT\u201029 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009&gt;\u2009300\u2009\u00b5M). Selectivity analysis demonstrated that compound\n                    <jats:bold>3<\/jats:bold>\n                    exhibited low toxicity toward healthy cells. In\u2009silico ADMET analysis indicated promising pharmacokinetic and physicochemical properties, including high gastrointestinal absorption, moderate lipophilicity, and compliance with drug\u2010likeness rules, while predicting limited blood\u2013brain barrier permeability. The BOILED\u2010Egg model further supported high intestinal absorption and peripheral activity.\n                  <\/jats:p>","DOI":"10.1002\/open.70314","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:47:28Z","timestamp":1790923648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Cytotoxic Activity of 1,3\u2010Selenazole\u20102\u2010Amine Derivatives With Computational ADMET Profiling"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6562-2554","authenticated-orcid":false,"given":"Gulay","family":"Dilek","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Department of Basic Pharmaceutical Sciences Zonguldak Bulent Ecevit University  Zonguldak T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-9425","authenticated-orcid":false,"given":"Senem","family":"Akkoc","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Basic Pharmaceutical Sciences Suleyman Demirel University  Isparta T\u00fcrkiye"},{"name":"Faculty of Engineering and Natural Sciences Bah\u00e7e\u015fehir University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Cancer","author":"World Health Organization","year":"2025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093233"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2022.100606"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101720125"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106896"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.3805"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02200\u201018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01535"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00804"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010012\u20100853\u20107"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.09.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.052"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010020\u201002641\u20101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/futurepharmacol2040036"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140606"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200890042"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27144328"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400063"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)61452\u20109"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.05.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010075"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5041149"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17568919.2024.2435254"},{"key":"e_1_2_9_25_1","first-page":"381","article-title":"A Comparison of the Biological Properties of 6\u2010Selenopurine, 6\u2010Selenopurine Ribonucleoside, and 6\u2010Mercaptopurine in Mice","volume":"20","author":"Jaffe J. 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