{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:37:40Z","timestamp":1785278260744,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:00:00Z","timestamp":1519344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Orexigen Therapeutics, Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp; Practice"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This multicenter, randomized, controlled, open\u2010label trial examined weight\u2010related quality of life, control over eating behaviour and sexual function after 26\u00a0weeks of treatment with either 32\u00a0mg naltrexone sustained release (SR)\/360\u00a0mg bupropion SR plus a comprehensive lifestyle intervention program (NB + CLI, <jats:italic>N<\/jats:italic>\u00a0=\u00a0153) or usual care (UC, <jats:italic>N<\/jats:italic>\u00a0=\u00a089), which included minimal lifestyle intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Impact of Weight on Quality of Life\u2010Lite, Binge Eating Scale and Arizona Sexual Experiences Scale were assessed at baseline (BL) and weeks 16 and 26.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NB + CLI and UC participants lost 9.46 and 0.94% respectively of initial body weight at week 26 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). NB + CLI participants had greater improvements in Impact of Weight on Quality of Life\u2010Lite total score than UC participants (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). In participants with moderate\/severe Binge Eating Scale scores at BL, 91% of NB + CLI and 18% of UC participants experienced categorical improvements. In participants with Arizona Sexual Experiences Scale\u2010defined sexual dysfunction at BL, 58% of NB + CLI and 19% of UC participants no longer met dysfunction criteria at week 26. The most frequent adverse events leading to discontinuation before week 26 in NB + CLI included nausea (10.5%); anxiety (3.3%); and headache, hypertension, insomnia and palpitations (1.3% each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with UC, participants treated with NB + CLI experienced greater improvements in weight\u2010related quality of life, control over eating behaviour, and sexual function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.156","type":"journal-article","created":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T13:47:38Z","timestamp":1516974458000},"page":"141-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Quality of life, binge eating and sexual function in participants treated for obesity with sustained release naltrexone\/bupropion"],"prefix":"10.1002","volume":"4","author":[{"given":"A.","family":"Halseth","sequence":"first","affiliation":[{"name":"Orexigen Therapeutics, Inc.  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Shan","sequence":"additional","affiliation":[{"name":"Orexigen Therapeutics, Inc.  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Gilder","sequence":"additional","affiliation":[{"name":"Orexigen Therapeutics, Inc.  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6627-4379","authenticated-orcid":false,"given":"M.","family":"Malone","sequence":"additional","affiliation":[{"name":"Orexigen Therapeutics, Inc.  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Orexigen Therapeutics, Inc.  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