{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:18:19Z","timestamp":1778602699563,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1 U54 GM104940"],"award-info":[{"award-number":["1 U54 GM104940"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U54 GM104940"],"award-info":[{"award-number":["1U54 GM104940"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp;amp; Practice"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was conducted to determine the role of obesity and race in intracerebral haemorrhage (ICH) outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Get with the guideline\u2010Stroke database was queried for all admitted patients with spontaneous ICH. Secondary causes of ICH were excluded. Body mass index (BMI) was classified using the Center for Disease Control guidelines. Race was classified as White or non\u2010White. Demographics, clinical, imaging data were retrieved. Outcome measures were hematoma expansion at 24\u00a0h and discharge disposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 428 patients were included in our analysis. Female gender, past history of congestive heart failure, diabetes mellitus, HbA1c, blood pressure, ICH volume, ICH location, intraventricular haemorrhage and hospital length of stay deferred across BMI categories. On multivariate analysis, along with obese categories, age, ICH location and ICH volume were independent predictors of poor outcomes (hematoma expansion and poor discharge disposition). After adjusting for these variables, obesity remained a predictor of poor disposition outcome compared with normal and overweight subjects; Normal vs. Obese OR 0.26 CI 0.115\u20130.593 <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0014; Obese vs. Overweight OR 3.79 CI 1.68\u20138.52 <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0013. Nonetheless, obesity did not influence hematoma expansion. Overall, BMI\u2010race classification did not influence outcomes. However, among non\u2010Whites, the obese category had higher odds of a poor disposition outcome than normal (OR 6.84 CI 2.12\u201322.22 <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0013) or overweight (OR 8.45 CI 2.6\u201327.49 <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0004) categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An obesity paradox in ICH was not observed in our cohort. In the non\u2010White population, patients with obesity were likely to be associated with poor disposition outcome. Similar findings were not observed in White population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.167","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T02:06:20Z","timestamp":1522461980000},"page":"268-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Racial differences in intracerebral haemorrhage outcomes in patients with obesity"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-7725","authenticated-orcid":false,"given":"I.","family":"Iwuchukwu","sequence":"first","affiliation":[{"name":"Department of Neurocritical Care, Neurology and Neurosurgery, Ochsner Medical Center\/Ochsner Clinical School University of Queensland  New Orleans LA USA"},{"name":"Neuroscience Center of Excellence Louisiana State University Health Science Center  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mahale","sequence":"additional","affiliation":[{"name":"Institute of Translation Research Ochsner Clinic Foundation  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ryder","sequence":"additional","affiliation":[{"name":"Ochsner Clinical School University of Queensland  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Ochsner Clinical School University of Queensland  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Department of Neurology Ochsner Medical Center  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Translation Research Ochsner Clinic Foundation  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Cornwell","sequence":"additional","affiliation":[{"name":"School of Public Health Louisiana State University Health Sciences Center  New Orleans LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Beyl","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Pennington Biomedical Research Center  Baton Rouge LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zabaleta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sothern","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine and School of Public Health Louisiana State University Health Sciences Center  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69251-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20468"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.09.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp317"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.06.031"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.10.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs340"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820b7667"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171334"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.576967"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666131227162950"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000691"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441907"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.6977795"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-013-0001-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.01.010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-016-0255-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.122093"},{"key":"e_1_2_7_23_1","first-page":"142","article-title":"Determinants of Inflammatory markers in a bi\u2010ethnic population","volume":"21","author":"Paalani M","year":"2011","journal-title":"Ethn Dis"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/174341"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.332"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00505.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.17.1855"}],"container-title":["Obesity Science &amp; Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fosp4.167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/osp4.167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:19:25Z","timestamp":1695507565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/osp4.167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,19]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/osp4.167"],"URL":"https:\/\/doi.org\/10.1002\/osp4.167","archive":["Portico"],"relation":{},"ISSN":["2055-2238","2055-2238"],"issn-type":[{"value":"2055-2238","type":"print"},{"value":"2055-2238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,19]]},"assertion":[{"value":"2018-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}