{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:12:07Z","timestamp":1792699927807,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp; Practice"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease worldwide and is characterized by insulin resistance, hepatic steatosis and often prediabetes or diabetes. Canagliflozin, a selective sodium glucose cotransporter 2 inhibitor, is a new oral anti\u2010diabetic drug that reduces hyperglycaemia by promoting urinary glucose excretion. Glycosuria produced by canagliflozin is associated with weight loss, mainly due to reduced fat volume and improve insulin resistance. Reduced body weight and improvement of insulin resistance by canagliflozin may be an effective treatment for NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five patients with NAFLD (17 men and 18 women) were enrolled and administered canagliflozin (100\u00a0mg). Body weight and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma\u2010glutamyl transferase (\u03b3\u2010GTP), low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol, triglycerides (TG), blood sugar (BS), glycated haemoglobin (HbA1C), uric acid (UA) and ferritin, and fibrosis\u20104 (FIB\u20104) index values were measured at baseline and at 3\u2010month and 6\u2010month follow\u2010up visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body weight and serum levels of AST, ALT, \u03b3\u2010GTP, TG, UA, HbA1C, BS and ferritin decreased significantly after 3 and 6\u00a0months of canagliflozin treatment. Serum BS levels and FIB\u20104 index values decreased slightly following 3\u00a0months of treatment; these results reached significance after 6\u00a0months. Reduced serum ALT levels at 6\u00a0months were significantly correlated with baseline HbA1C and ferritin levels. Moreover, a significant correlation between reduced body weight and serum ALT levels was observed at 6\u00a0months. Decreased serum ALT levels were significantly correlated with decreased serum ferritin at 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Canagliflozin significantly reduced the serum levels of BS, HbA1C, TG, UA and ferritin, as well as FIB\u20104 index values and body weight, with improved liver function. Sodium glucose cotransporter 2 inhibitors may be an important therapeutic modality for improving liver injury in NAFLD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.294","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T12:17:54Z","timestamp":1533298674000},"page":"477-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Efficacy of canagliflozin against nonalcoholic fatty liver disease: a prospective cohort study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-0436","authenticated-orcid":false,"given":"Toshio","family":"Itani","sequence":"first","affiliation":[{"name":"Asahi Clinic  Mie District Mie Prefecture Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6866-7547","authenticated-orcid":false,"given":"Tomoaki","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Yokkaichi Digestive Disease Center  Yokkaichi City Mie Prefecture Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011775"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)30864-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.04.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31825-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2015.02.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2015.10.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr2467w"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0264-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01526.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004619"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-4-201308200-00007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.1909"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-015-0102-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaclin.23.3.115"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80287-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.200787"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.027581"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24706"},{"key":"e_1_2_7_23_1","first-page":"48","article-title":"Phlebotomy in the treatment of iron overload in patients with nonalcoholic and alcoholic fatty liver diseases","volume":"2","author":"Penkowa M","year":"2012","journal-title":"Int J Bus Hum Tech."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.63.03.284"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000213Y.0000000050"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01774.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-009-9814-x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2009.07.003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.11.004"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302009000200012"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000233"}],"container-title":["Obesity Science &amp; 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