{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:07:41Z","timestamp":1773788861973,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["F32 DK103474"],"award-info":[{"award-number":["F32 DK103474"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["R01 AG043471"],"award-info":[{"award-number":["R01 AG043471"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["R01 DK100431"],"award-info":[{"award-number":["R01 DK100431"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["ULTR000445"],"award-info":[{"award-number":["ULTR000445"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009210","name":"Food and Drug Administration","doi-asserted-by":"publisher","award":["R01 FD04778\u201002"],"award-info":[{"award-number":["R01 FD04778\u201002"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18IPA34110172"],"award-info":[{"award-number":["18IPA34110172"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp; Practice"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Every year, over 200 000 individuals undergo bariatric surgery for the treatment of extreme obesity in the United States. Several retrospective studies describe the occurrence of orthostatic intolerance (OI) syndrome after bariatric surgery. However, the incidence of this syndrome remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We used a prospective, de\u2010identified registry of 4547 patients who have undergone bariatric surgery at Vanderbilt to identify cases of new\u2010onset OI. Structured chart reviews were conducted for all subjects who reported new\u2010onset OI post surgery. Cases of OI were confirmed using an operational case definition developed by the Vanderbilt Autonomic Dysfunction Center, and autonomic function tests results were examined for evidence of impaired autonomic function. The cumulative incidence of post\u2010bariatric surgery OI syndrome was estimated using a life table.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven hundred forty\u2010one of 4547 (16.3%) patients included in our cohort reported new OI symptoms after surgery. After the chart review, we confirmed the presence of post\u2013bariatric surgery OI syndrome in 85 patients, 14 with severe OI requiring pressor agents. At 5 years post surgery, follow\u2010up is reduced to 15%; the unadjusted 5\u2010year prevalence of OI was 1.9%. The cumulative incidence of OI syndrome adjusted for loss of follow\u2010up was 4.2%. Most OI cases developed during weight\u2010stable months (\u00b15 kg). At the time of identification, 13% of OI cases showed evidence of impaired sympathetic vasoconstrictor activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OI is frequent in the bariatric population, affecting 4.2% of patients within the first 5 years postoperatively. In 13% of post\u2013bariatric surgery OI patients, there was evidence of impaired sympathetic vasoconstriction activity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.383","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T18:52:38Z","timestamp":1573239158000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The incidence of orthostatic intolerance after bariatric surgery"],"prefix":"10.1002","volume":"6","author":[{"given":"James B.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6398-935X","authenticated-orcid":false,"given":"Robyn A.","family":"Tamboli","sequence":"additional","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5267-8951","authenticated-orcid":false,"given":"Vance L.","family":"Albaugh","sequence":"additional","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Kilkelly","sequence":"additional","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos G.","family":"Grijalva","sequence":"additional","affiliation":[{"name":"Department of Health Policy Vanderbilt University Medical Center  Nashville Tennessee"},{"name":"Mid\u2010South Geriatric Research Education and Clinical Center VA Tennessee Valley Health Care System  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-6801","authenticated-orcid":false,"given":"Cyndya A.","family":"Shibao","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Obesity and overweight factsheet from the WHO.http:\/\/www.thehealthwell.info\/node\/82914. 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