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In this study, the effect of a novel modified\u2010release fixed\u2010dose combination of orlistat and acarbose (MR\u2010OA) was compared with conventional orlistat (CO) regarding tolerability, appetite and glucose metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven men with obesity, aged 24 to 60 years with body mass indexes (BMIs) 33 to 40 kg m<jats:sup>\u22122<\/jats:sup> or BMIs 30 to 32 kg m<jats:sup>\u22122<\/jats:sup> and waist circumference above 102 cm were included. They were randomized to either three different doses of the test formulation MR\u2010OA (60 mg orlistat\/20 mg acarbose, 90\/30 and 120\/40) or CO (Xenical, 120 mg orlistat) for a 2\u2010week study of daily treatment. The participants spent days 1 and 14 at the clinical research centre where they received standardized meals, had blood sampling and filled in questionnaires regarding tolerability and appetite after meals. In days 2 to 13, the participants were at home and continued to fill in the questionnaires daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the MR\u2010OA groups, reports of liquid and oily stools as well as faecal incontinence were fewer, whereas reports of gastric distension and flatulence were higher, compared with the CO group. More participants reported decreased hunger in the 90\/30 and 120\/40 MR\u2010OA, and postprandial plasma glucose concentration was reduced in all MR\u2010OA groups compared with CO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that by using a modified\u2010release dosage form, orlistat and acarbose can be combined without compromising tolerability. Furthermore, MR\u2010OA shows promising effects regarding reduction of appetite and reduces postprandial glucose. Tolerability is coupled to compliance and thereby efficacy of a treatment; therefore, this novel combination MR\u2010OA could be an effective approach for weight loss treatment. A follow\u2010up study in a more diverse population and for a longer duration with weight loss as primary outcome variable is planned.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.405","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T16:27:46Z","timestamp":1579710466000},"page":"313-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0764-5878","authenticated-orcid":false,"given":"Ulf","family":"Holmb\u00e4ck","sequence":"first","affiliation":[{"name":"Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-4556","authenticated-orcid":false,"given":"Anders","family":"Forslund","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Grud\u00e9n","sequence":"additional","affiliation":[{"name":"Empros Pharma AB  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Alderborn","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvid","family":"S\u00f6derh\u00e4ll","sequence":"additional","affiliation":[{"name":"Empros Pharma AB  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-0772","authenticated-orcid":false,"given":"Per M.","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-5184","authenticated-orcid":false,"given":"Hans","family":"Lennern\u00e4s","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-018-0300-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v2.i2.19"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12657"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.272815"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.46"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.11.1733"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.7602"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0210"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","unstructured":"FransonK R\u00f6ssnerS.Fat intake and food choices during weight reduction with diet behavioural modification and a lipase inhibitor.2000.","DOI":"10.1046\/j.1365-2796.2000.t01-1-00666.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2009.00581.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12606"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13399"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1591-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0924"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2010.07.010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90209.2008"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030199"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200222030-00001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2002.0565"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.06.025"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2014.01.019"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"S307","article-title":"Acarbose improves glycemic control and reduces body weight: Subanalysis data of South Asia region","volume":"17","author":"Kalra S","year":"2013","journal-title":"Indian J. 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