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There is a medical need for nonsystemic treatments that promote weight loss in patients with overweight or early obesity. This report reviews four different approaches of utilizing superabsorbent hydrogel technology for weight management at varying stages of preclinical and clinical development. The first is a nonsystemic, oral superabsorbent hydrogel created from naturally derived building blocks used in foods (cellulose\u2010based), designed to mix homogenously with and change the properties of the ingested meal throughout the gastrointestinal tract (stomach and small intestine). This is the first\u2010in\u2010class to be cleared by the Food and Drug Administration (FDA) to aid in weight\u2010management for adults with BMI of 25\u201340 kg\/m<jats:sup>2<\/jats:sup> in conjunction with diet and exercise. In contrast, the other three approaches in development utilize superabsorbent hydrogel technologies to support an intragastric balloon\u2010like structure, solely occupying space in the stomach and displacing the meal: (1) a pufferfish\u2010inspired device; (2) Epitomee, a pH\u2010sensitive self\u2010expanding hydrogel device; and (3) a light\u2010degradable hydrogel used to control balloon deflation. These new approaches that utilize superabsorbent hydrogel technology offer a wide range of clinical applicability and have the potential to broaden the weight management treatment landscape. Over time, increasing the number of patients treated with superabsorbent hydrogel technologies will provide important information on long\u2010term efficacy and safety.<\/jats:p>","DOI":"10.1002\/osp4.574","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T03:10:11Z","timestamp":1637377811000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Recent advances in therapies utilizing superabsorbent hydrogel technology for weight management: A review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-9401","authenticated-orcid":false,"given":"Louis J.","family":"Aronne","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, &amp; Metabolism Comprehensive Weight Control Center Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Anderson","sequence":"additional","affiliation":[{"name":"The Frist Clinic  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sannino","sequence":"additional","affiliation":[{"name":"Gelesis, Inc.  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