{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:59Z","timestamp":1786978259833,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science & Practice"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The Diabetes Prevention Program (DPP) is the gold standard lifestyle modification program that reduces incident type 2 diabetes mellitus. Patients with prediabetes and patients with non\u2010alcoholic fatty liver disease (NAFLD) often share metabolic features; we hypothesized that the DPP could be adapted and used to improve outcomes in patients with NAFLD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n NAFLD patients were recruited into a 1\u00a0year modified DPP. Demographics, medical comorbidities, and clinical laboratory values were collected at baseline, 6 and 12\u00a0months. The primary endpoint was change in weight at 12\u00a0months. Secondary endpoints were changes in hepatic steatosis, metabolic comorbidities, and liver enzymes (per\u2010protocol basis) and retention at 6 and 12\u00a0months.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fourteen NAFLD patients enrolled; three dropped out before 6\u00a0months. From baseline to 12\u00a0months, hepatic steatosis (\n p<\/jats:italic>\n \u00a0=\u00a00.03), alanine aminotransferase (\n p<\/jats:italic>\n \u00a0=\u00a00.02), aspartate aminotransferase (\n p\u00a0=<\/jats:italic>\n 0.02), high\u2010density lipoprotein (\n p<\/jats:italic>\n \u00a0=\u00a00.01) and NAFLD fibrosis score (\n p<\/jats:italic>\n \u00a0<\u00a00.001) improved, but low\u2010density lipoprotein worsened (\n p<\/jats:italic>\n \u00a0=\u00a00.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Seventy\u2010nine percent of patients completed the modified DPP. Patients lost weight and had improvements in five out of six indicators of liver injury and lipid metabolism.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registry Number<\/jats:title>\n NCT04988204.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/osp4.637","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T11:20:38Z","timestamp":1661512838000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Modification of the diabetes prevention program for the treatment of nonalcoholic fatty liver disease: A pilot study"],"prefix":"10.1002","volume":"9","author":[{"given":"Melissa","family":"Hershman","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Oregon Health & Science University Portland Oregon USA"},{"name":"Department of Gastroenterology and Hepatology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Torbjornsen","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T.","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponni V.","family":"Perumalswami","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Division of Gastroenterology and Liver Diseases University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea D.","family":"Branch","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-4345","authenticated-orcid":false,"given":"Amreen M.","family":"Dinani","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases Icahn School of Medicine at Mount Sinai New York New York 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