{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:44:40Z","timestamp":1747151080310,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp;amp; Practice"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many of the drugs used for obesity treatment have adverse effects on the central nervous system. Therefore, novel treatments, such as peripherally acting drugs, are needed. Monoacylglycerol acyltransferase 2 (MGAT2), highly expressed in the small intestine, catalyzes the first step of triacylglycerol re\u2010synthesis. MGAT2 inhibition suppresses food intake in high\u2010fat diet (HFD)\u2010fed mice, but the mechanisms remain unclear. Here, the involvement of the vagus nerve in MGAT2 inhibition\u2010induced feeding suppression was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fasted mice were administered an MGAT2 inhibitor. Food intake was measured after HFD re\u2010feeding, and the effect of capsaicin pretreatment on changes in food intake was evaluated. The number of c\u2010fos\u2010positive cells in the nucleus tractus solitarius and levels of appetite regulators were determined after HFD re\u2010feeding or lipid gavage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The anorectic effect of the MGAT2 inhibitor was abolished when vagus nerve function was interrupted by capsaicin. MGAT2 inhibition increased the number of c\u2010fos\u2010positive cells in the nucleus tractus solitarius and elevated intestinal oleoylethanolamide, plasma peptide tyrosine\u2013tyrosine and plasma glucagon\u2010like peptide\u20101 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MGAT2 inhibition suppresses feeding behavior via peripheral vagus nerve signaling and may serve as a novel anti\u2010obesity strategy with a low risk of unexpected central nervous system\u2010related adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.693","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T08:43:55Z","timestamp":1687682635000},"page":"601-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Involvement of the vagus nerve in the anorectic effect of monoacylglycerol acyltransferase 2 inhibition in mice"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-4649","authenticated-orcid":false,"given":"Kosuke","family":"Takemoto","sequence":"first","affiliation":[{"name":"Drug Discovery &amp; Disease Research Laboratory Shionogi &amp; Co., Ltd.  Osaka Japan"},{"name":"Laboratory of Veterinary Pathology Joint Faculty of Veterinary Medicine Yamaguchi University  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Drug Discovery &amp; Disease Research Laboratory Shionogi &amp; Co., Ltd.  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Higashino","sequence":"additional","affiliation":[{"name":"Drug Discovery &amp; Disease Research Laboratory Shionogi &amp; Co., Ltd.  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010021\u201000337\u20108"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1003114"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08\u2010s258"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(10)60888\u20104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1411892"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010021\u201002945\u20101"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m300139200"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1937"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.r052902"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021\u20109258(18)93813\u20105"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m301633200"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.09.021"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m114.555961"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20100647"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12643"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00512.2002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00220.2005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/35102582"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.11.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.063"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.03.011"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150976"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00344.2014"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7268408"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00114.2011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.03.072"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.12778"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102362.1992.tb01464.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050913"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006\u20100557"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010014\u20101259\u20101"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1600869"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010020\u201004877\u20107"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12567"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.95.3.9983"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.006"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010016\u20102062\u2010y"}],"container-title":["Obesity Science &amp; Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/osp4.693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T15:30:46Z","timestamp":1703604646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/osp4.693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/osp4.693"],"URL":"https:\/\/doi.org\/10.1002\/osp4.693","archive":["Portico"],"relation":{},"ISSN":["2055-2238","2055-2238"],"issn-type":[{"type":"print","value":"2055-2238"},{"type":"electronic","value":"2055-2238"}],"subject":[],"published":{"date-parts":[[2023,7,6]]},"assertion":[{"value":"2022-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}