{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:59:59Z","timestamp":1775059199651,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp;amp; Practice"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Glucagon\u2010like peptide\u20101 receptor (GLP\u20101R) agonists are well\u2010established therapies for obesity and type 2 diabetes mellitus (T2DM). Emerging evidence also suggests their potential role in managing obstructive sleep apnea (OSA). This study aimed to investigate the association between GLP\u20101R agonists and OSA using genetic evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cis\u2010expression quantitative trait loci (cis\u2010eQTLs) associated with the <jats:italic>GLP1R<\/jats:italic> gene were identified and used as genetic proxies for GLP\u20101R agonist exposure. To validate the selected genetic instruments, positive control analyses were conducted for T2DM and body mass index (BMI). Mendelian randomization was employed to evaluate the effect of genetically proxied GLP\u20101R agonists on OSA. OSA data were obtained from FinnGen Release 11 (R11), comprising 50,200 cases and 401,484 controls of European ancestry. The inverse variance weighted (IVW) method served as the primary analytical approach, supplemented by heterogeneity tests and sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IVW analysis showed that genetically predicted GLP\u20101R agonist exposure was associated with a reduction in BMI (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.063, 95% confidence interval [CI]: \u22120.10 to \u22120.03, <jats:italic>p<\/jats:italic>\u00a0=\u00a08.43\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>) and a decreased risk of T2DM (odds ratio [OR]\u00a0=\u00a00.80, 95% CI: 0.65 to 0.98, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.032), supporting the validity of the genetic instruments. Notably, GLP\u20101R agonists were also associated with a significantly lower risk of OSA (OR\u00a0=\u00a00.83, 95% CI: 0.76 to 0.91, <jats:italic>p<\/jats:italic>\u00a0=\u00a06.15\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>). No evidence of heterogeneity or horizontal pleiotropy was detected, and leave\u2010one\u2010out analysis confirmed the robustness of the findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides genetic evidence supporting the protective role of GLP\u20101R agonists against OSA, highlighting their potential as a therapeutic strategy for OSA management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.70090","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:40:15Z","timestamp":1755862815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Glucagon\u2010Like Peptide 1 Receptor Agonists on Obstructive Sleep Apnea"],"prefix":"10.1002","volume":"11","author":[{"given":"Bei\u2010Bei","family":"Qian","sequence":"first","affiliation":[{"name":"Northern Jiangsu People's Hospital Northern Jiangsu People's Hospital Affiliated to Yangzhou University  Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"Huaian Cancer Hospital  Huaian Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1127-0690","authenticated-orcid":false,"given":"Cai\u2010Feng","family":"Yan","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People's Hospital Northern Jiangsu People's Hospital Affiliated to Yangzhou University  Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Yong","family":"Feng","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People's Hospital Northern Jiangsu People's Hospital Affiliated to Yangzhou University  Yangzhou Jiangsu 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