{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:23:21Z","timestamp":1789673001162,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp;amp; Practice"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Obesity\u2010related complications (ORCs) are associated with substantial health and economic burdens. Although treatment targets are routinely used for other chronic conditions, none currently exist in obesity management. We aimed to identify an adiposity measure that indicates a reduced risk of four ORCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This population\u2010based cohort study of patients aged 18\u201360\u00a0years used data from the UK Clinical Practice Research Datalink Aurum. Associations between absolute 10\u2010year ORC risk and baseline body mass index (BMI), waist\u2013height ratio (WHtR), and changes in adiposity measures after weight loss were calculated. Absolute values and changes in adiposity measures were evaluated as a proxy for achieving an absolute 10\u2010year ORC risk similar to that of people without obesity, and optimal cut\u2010offs were identified based on the balance between true positive and true negative rates for achieving the treatment goal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Absolute values of BMI and WHtR post\u2010weight change were more strongly associated with 10\u2010year ORC risk than relative changes; WHtR was the best proxy for a low absolute risk for type 2 diabetes, hypertension, and atherosclerotic cardiovascular disease, and BMI for hip\/knee osteoarthritis. Based on the balance between true negative and true positive rates of multiple cut\u2010offs, a BMI \u2264\u00a027\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and WHtR \u2264\u00a00.53 are proposed as potential treatment targets for obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that treatment goals for obesity management may be considered on post\u2013weight\u2010change absolute adiposity measures, rather than relative changes. Both weight and WHtR may be considered when defining treatment targets for ORC risk reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/osp4.70094","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T07:20:59Z","timestamp":1762413659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Identification of Potential Treatment Targets to Reduce the Risk of Obesity\u2010Related Complications: A Step Toward a Treat\u2010to\u2010Target Approach in Obesity Management"],"prefix":"10.1002","volume":"11","author":[{"given":"Luca","family":"Busetto","sequence":"first","affiliation":[{"name":"Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Schnecke","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Overvad","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Capucci","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Reynoso","sequence":"additional","affiliation":[{"name":"Novo Nordisk Health Care  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Bravo","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd A.","family":"Tahrani","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"},{"name":"Metabolism and Systems Science University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla S.","family":"Morgen","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Obesity Federation World Obesity Atlas (2024) accessed October 14 2025 \u00a0https:\/\/data.worldobesity.org\/publications\/WOF\u2010Obesity\u2010Atlas\u2010v7.pdf."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(22)00033\u2010x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614362"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes23016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442721"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101850"},{"key":"e_1_2_9_8_1","unstructured":"World Health Organization Obesity and Overweight Fact Sheets (2025) accessed October 14 2025 \u00a0www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003198"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010023\u201001376\u20104"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010021\u201000788\u20104"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u2010S008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15154"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(14)70156\u20101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2022.08.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4158\/ep161356.esgl"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/964236"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22\u20100034"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.120.15026"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010021\u201001217\u20101"},{"key":"e_1_2_9_22_1","unstructured":"European Medicines Agency Clinical Evaluation of Medicinal Products Used in Weight Control \u2010 Scientific Guideline Accessed March 1 2024 https:\/\/www.ema.europa.eu\/en\/clinical\u2010evaluation\u2010medicinal\u2010products\u2010used\u2010weight\u2010control\u2010scientific\u2010guideline."},{"key":"e_1_2_9_23_1","unstructured":"U.S. Food and Drug Administration Developing Products for Weight Management Revision 1. 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