{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:21:21Z","timestamp":1789057281484,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015519","name":"WW International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015519","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp; Practice"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Newer generation anti\u2010obesity medications such as semaglutide and tirzepatide are highly efficacious, resulting in a proliferation of telehealth prescribers. Few, however, augment medication with a behavioral intervention, and little research has examined the impact of these medications on psychosocial variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated the efficacy of a telehealth provision of semaglutide\/tirzepatide with a virtual behavioral program on psychosocial outcomes at 12 and 24\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010arm pragmatic trial, 180 participants (M age\u00a0=\u00a044.1; 91% female; 81% white; M weight\u00a0=\u00a0102.6\u00a0kgs) were recruited from a telemedicine obesity program (WeightWatchers Clinic) and offered an adjunctive virtual behavioral program tailored for patients on long\u2010acting incretin therapy. Participants completed the PHQ\u20108 measuring depression, Perceived Stress Scale, Self\u2010Compassion Scale, WHO\u20105 measuring well\u2010being, Weight Bias Internalization Scale\u20102F and Impact of Weight on Quality of Life\u2010Lite at baseline, 12 and 24 weeks. Wilcoxon signed\u2010rank tests were conducted to evaluate outcome differences.\n                      <jats:italic>p<\/jats:italic>\n                      values were adjusted using a False Discovery Rate approach. Intent\u2010to\u2010treat analysis was performed using last observation carried forward (LOCF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were significant improvements from median baseline to 24\u00a0weeks in measures of depression (\u22122), perceived stress (\u22123), well\u2010being (3), weight bias internalization (\u22120.6), and impact of weight on quality of life (\u221218). All\n                      <jats:italic>p<\/jats:italic>\n                      's\u00a0&lt;\u00a00.001 in the baseline to 24\u2010week analyses with similar results shown at 12 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Virtually delivered obesity treatment combining telemedicine and a long\u2010acting incretin\u2010specific behavioral program demonstrated clinically significant improvements in psychosocial outcomes over 24\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/osp4.70149","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:52:42Z","timestamp":1779335562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Psychosocial Outcomes in Telemedicine and Long\u2010Acting Incretin\u2010Specific Behavioral Intervention"],"prefix":"10.1002","volume":"12","author":[{"given":"Leslie J.","family":"Heinberg","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology Cleveland Clinic Lerner College of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Lee","sequence":"additional","affiliation":[{"name":"WW International Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Foster","sequence":"additional","affiliation":[{"name":"Weight and Eating Disorders Program Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Zajichek","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Nadolsky","sequence":"additional","affiliation":[{"name":"Vineyard Health  Livermore California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"DiVita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rotroff","sequence":"additional","affiliation":[{"name":"Lerner Research Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle I.","family":"Cardel","sequence":"additional","affiliation":[{"name":"Department Health Outcomes &amp; Biomedical Informatics University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Department of Pharmaceutical Outcomes &amp; Policy University of Florida College of Pharmacy  Gainesville Florida USA"},{"name":"Center for Integrative Cardiovascular &amp; Metabolic Disease University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23619"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15620"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16046"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2023.08.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.23385"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201075965\u20102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002672\u20102"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.10.062"},{"key":"e_1_2_8_11_1","unstructured":"A.Montero G.Sparks A.Kirzinger I.Valdes andL.Hamel KFF Health Tracking Poll July 2023: The Public\u2019s Views of New Prescription Weight Loss Drugs and Prescription Drug Costs(2023)."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23548"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23382"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24169"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.70056"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278\u20106133.19.6.586"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.026"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101497.2001.016009606.x"},{"key":"e_1_2_8_19_1","unstructured":"American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed.(1994)."},{"key":"e_1_2_8_20_1","volume-title":"The Social Psychology of Health: Claremont Symposium on Applied Social Psychology","author":"Cohen S.","year":"1988"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.702"},{"key":"e_1_2_8_22_1","volume-title":"The World Health Organization\u2010Five Well\u2010Being Index (WHO\u20105)","author":"World Health Organization","year":"2024"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.00808"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.13"},{"key":"e_1_2_8_25_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2022"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.4346"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2025.02.008"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-02520-4"},{"key":"e_1_2_8_28_2","unstructured":"https:\/\/doi.org\/10.1186\/s12888\u2010020\u201002520\u20104."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13150"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000376585"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-025-03266-9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.354"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679\u2010025\u201000611\u20105"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjhp.12686"},{"key":"e_1_2_8_35_1","article-title":"Effectiveness of a Digital Weight Management Program on Weight\u2010Bias Internalization, Self\u2010Compassion, Quality of Life, Well\u2010Being, and Body Appreciation: Secondary Outcomes From a Randomized Controlled Trial","author":"Palacios A. 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