{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:50:11Z","timestamp":1782399011756,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp; Practice"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>As patient response to obesity medication can vary, it is crucial to identify both those likely and unlikely to respond to treatment. This post hoc analysis aimed to examine predictive characteristics in patients who achieved weight\u2014related targets with fixed\u2010dose, extended\u2010release combination of naltrexone and bupropion (NB\u2010ER).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This pooled analysis included patients from three Phase 3, placebo\u2010controlled COR trials (NCT00532779, NCT00567255, NCT00456521). The impact of baseline characteristics in predicting changes in weight\u2010related anthropometric targets at 56\u00a0weeks in those who completed treatment and were \u2265\u00a090% adherent to NB\u2010ER was evaluated with univariable and multivariable analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1692 patients analyzed, similar proportions of patients receiving NB\u2010ER versus placebo were female and White. Among patients treated with NB\u2010ER with \u2265\u00a090% adherence, 73.2% achieved \u2265\u00a05% body weight (BW) reduction, 47.6% achieved \u2265\u00a010% BW reduction, 27.8% achieved \u2265\u00a015% BW reduction, 33.7% achieved target body mass index, and 23.7% achieved target waist circumference thresholds. Among the baseline characteristics assessed, female sex and White race most consistently predicted the likelihood of achieving the target outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adherence to NB\u2010ER was associated with achieving anthropometric targets; however, the ability to predict a successful response in advance of NB\u2010ER treatment is still limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/osp4.70159","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:30:57Z","timestamp":1781595057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Predictors of Weight\u2010Related Outcomes With Fixed\u2010Dose, Extended\u2010Release Naltrexone and Bupropion Among Treatment\u2010Adherent Patients in Phase 3 COR Trials: A Treatment Target Analysis"],"prefix":"10.1002","volume":"12","author":[{"given":"Donna H.","family":"Ryan","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-5994","authenticated-orcid":false,"given":"Angela","family":"Fitch","sequence":"additional","affiliation":[{"name":"knownwell  Needham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-3705","authenticated-orcid":false,"given":"Robert F.","family":"Kushner","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jena S.","family":"Tronieri","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Still","sequence":"additional","affiliation":[{"name":"Geisinger Commonwealth School of Medicine  Danville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-1922","authenticated-orcid":false,"given":"Caroline M.","family":"Apovian","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Center for Weight Management and Wellness  Boston Massachusetts 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