{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:22:17Z","timestamp":1787808137212,"version":"build-2784847793"},"reference-count":95,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp;amp; Practice"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review synthesized the components of lifestyle interventions that have been provided in Phase 3 trials of obesity management medications (OMMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, CINAHL, and EMBASE were searched for Phase 3 clinical trials published from inception to February 2026 that tested FDA\u2010approved OMMs. We descriptively synthesized lifestyle intervention components including dietary, physical activity, and delivery of counseling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 50 reports from 42 studies. Most of the studies included a calorie restriction goal of 500\u00a0kcals\/day. The most common physical activity goal recommended was\u00a0\u2265\u00a0150\u00a0min\/week. Diaries for eating and tracking physical activity have been recommended in many studies. There were 22 studies that provided counseling at least monthly or more frequently and an additional 16 trials that provided counseling at least every 3\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lifestyle interventions have been core components in Phase 3 trials of FDA\u2010approved OMMs. Further research is needed to test the optimal lifestyle interventions that should be provided along OMMs to maximize health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/osp4.70162","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:26:50Z","timestamp":1783600010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Review of Lifestyle Interventions Provided as an Adjunct to Obesity Management Medications"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-8973","authenticated-orcid":false,"given":"Ariana M.","family":"Chao","sequence":"first","affiliation":[{"name":"Johns Hopkins School of Nursing  Baltimore Maryland USA"},{"name":"Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ransford","family":"Asante","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maame Efua","family":"Sersah","sequence":"additional","affiliation":[{"name":"Department of Child Health Korle bu Teaching Hospital  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar Anwar","family":"Jahangir","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Peary","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Nursing  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kudaya","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010024\u201001525\u20103"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1212914"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1109220"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266217"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010020\u201006548\u2010w"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.10816"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.2.218"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.147"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679\u2010023\u201000534\u2010z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12932"},{"key":"e_1_2_10_13_1","unstructured":"Novo Nordisk Wegovy (Package Insert) https:\/\/www.novo\u2010pi.com\/wegovy.pdf."},{"key":"e_1_2_10_14_1","unstructured":"Eli Lilly and Company Zepbound (Package Insert) https:\/\/pi.lilly.com\/us\/zepbound\u2010uspi.pdf."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.07.010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007218"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1411892"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2032183"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2206038"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(25)00226\u20108"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2500969"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.028381"},{"key":"e_1_2_10_23_1","unstructured":"Food and Drug Administration Guidance for Industry: Developing Products for Weight Management (Draft Guidance) (2017)."},{"key":"e_1_2_10_24_1","article-title":"Obesity and Overweight: Developing Drugs and Biological Products for Weight Reduction Draft Guidance for Industry. 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