{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:50:07Z","timestamp":1782399007993,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010387","name":"Universidad de Sonora","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp; Practice"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity is a major public health crisis in Mexico. With internet usage rapidly increasing, digital health interventions present a clear opportunity for treating obesity. This study addressed a key gap in research by evaluating a web\u2010based Intensive Lifestyle Modification intervention adapted from the Diabetes Prevention Program for weight loss (DPP\u2010web) in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy of the DPP\u2010web in Mexican adults with overweight or obesity at 3 and 6\u00a0months compared with a wait\u2010list control group, a randomized controlled trial (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a062) with two groups was conducted. The primary outcome was the change in weight at 3\u00a0months, with secondary outcomes including changes in anthropometric parameters, quality of life and depressive symptoms at three and 6\u00a0months, and biochemical measures at 3\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants, predominantly women (81%), with an average age of 31.5\u00a0\u00b1\u00a08.6\u00a0years and BMI of 33.4\u00a0\u00b1\u00a04.85\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , had retention rates of 77% at 3\u00a0months and 60% at 6\u00a0months. The treatment effect by intention\u2010to\u2010treat analysis was \u22123.65\u00a0kg (95% CI \u22125.41, \u22121.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) at 3\u00a0months and \u22125.50\u00a0kg (95% CI \u22127.58, \u22123.41) at 6\u00a0months, favoring the DPP\u2010group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The DPP\u2010web was effective for weight loss in the Mexican population at three and 6\u00a0months and could help to improve access to an effective obesity treatment in Spanish\u2010speaking countries, including Mexico.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/osp4.70165","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:50:37Z","timestamp":1781855437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of an Online Weight Loss Program for Mexican Adults: Findings From a Randomized Controlled Trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-0874","authenticated-orcid":false,"given":"Alma Lorena","family":"Ruelas Yanes","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas, Facultad Interdisciplinaria de Ciencias Biol\u00f3gicas y de Salud Universidad de Sonora Encinas y Rosales s\/n  Hermosillo M\u00e9xico"},{"name":"Departamento de Nutrici\u00f3n Facultad de Medicina Mexicali Universidad Aut\u00f3noma de Baja California Humberto Torres Sangin\u00e9s s\/n, Centro C\u00edvico  Mexicali M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-7545","authenticated-orcid":false,"given":"Teresita de Jes\u00fas","family":"Mart\u00ednez\u2010Contreras","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas, Facultad Interdisciplinaria de Ciencias Biol\u00f3gicas y de Salud Universidad de Sonora Encinas y Rosales s\/n  Hermosillo M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-4136","authenticated-orcid":false,"given":"Maria del Carmen","family":"Candia\u2010Plata","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Ciencias de la Salud, Facultad Interdisciplinaria de Ciencias Biol\u00f3gicas y de Salud Universidad de Sonora Encinas y Rosales s\/n  Hermosillo M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-2031","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Esparza\u2010Romero","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Obesidad y Diabetes Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo A.C.  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