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Therefore, this study investigated the effects of weight loss interventions on laboratory and clinical parameters in children and adolescents with NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Original databases (PubMed\/MEDLINE, Web of Science, SCOPUS, and Embase) were searched using standard keywords to identify all controlled trials investigating the effects of weight loss interventions among NAFLD children and adolescents. Pooled weighted mean difference and 95% confidence intervals were achieved by random\u2010effects model analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen eligible clinical trials were included in this systematic review and meta\u2010analysis. The pooled findings showed that especially more intense weight loss interventions significantly reduced the glucose (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), insulin (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), homeostatic model assessment\u2010insulin resistance (HOMA\u2010IR) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), weight (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.025), body mass index (BMI) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), BMI <jats:italic>z<\/jats:italic>\u2010score (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), waist circumference (WC) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013), triglyceride (TG) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and aspartate transaminase (AST) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027). However, no significant changes were found in total cholesterol, low\u2010density lipoprotein cholesterol (LDL\u2010C), high\u2010density lipoprotein cholesterol (HDL\u2010C), alanine transaminase (ALT), and hepatic steatosis grades (all <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05) following weight loss interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weight loss interventions had significant effects on NAFLD\u2010related parameters including glucose, insulin, HOMA\u2010IR, weight, BMI, BMI z\u2010score, WC, TG, and AST.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.758","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T11:45:35Z","timestamp":1714131935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effects of weight loss interventions on children and adolescents with non\u2010alcoholic fatty liver disease: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-7112","authenticated-orcid":false,"given":"Mohammad Hassan","family":"Sohouli","sequence":"first","affiliation":[{"name":"Student Research Committee Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Pediatric Gastroenterology and Hepatology Research Center Pediatrics Centre of Excellence Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Elaheh","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somaye","family":"Fatahi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Research 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