{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:49:21Z","timestamp":1786477761342,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp;amp; Practice"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiologic findings suggest that measures of body fat distribution predict health outcomes independent of the overall body fat assessed by body mass index (BMI). This study aimed to evaluate the associations of overall and regional body fat with the severity of hepatic steatosis and fibrosis in type 2 diabetic patients with non\u2010alcoholic fatty liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bioelectric impedance analysis and two newly developed anthropometric indices, namely, A Body Shape Index (ABSI) and Body Roundness Index (BRI), were used to estimate the body fat. Based on fibroscan parameters, significant hepatic fibrosis and severe steatosis were defined as \u2265F2 and &gt;66%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher total body fat (odds ratio [OR] 1.107, 95% confidence intervals (CI) 1.038\u20131.182, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), trunk fat (OR 1.136, 95% CI 1.034\u20131.248, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) and leg fat (OR 1.381, 95% CI 1.139\u20131.674, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) were associated with liver fibrosis. However, in contrast to the total body fat (OR 1.088, 95% CI 1.017\u20131.164, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014) and leg fat (OR 1.317, 95% CI 1.066\u20131.628, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011), the trunk fat was not associated with severe hepatic steatosis. BRI performed better than trunk, leg and total body fat in predicting hepatic steatosis (OR 2.186, 95% CI 1.370\u20133.487, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and fibrosis (OR 2.132, 95% CI 1.419\u20133.204, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Moreover, the trunk to leg fat ratio and ABSI were not independent predictors of either steatosis or fibrosis (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BRI revealed a superior predictive ability for identifying the degree of hepatic steatosis and stiffness than other obesity indices. Additionally, higher levels of adiposity in the trunk, legs, and overall body were linked to an increased risk of developing liver fibrosis. Although trunk fat did not show an association with severe hepatic steatosis, an increase in leg and total fat was related to liver steatosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/osp4.777","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T14:24:35Z","timestamp":1719843875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regional fat distribution and hepatic fibrosis and steatosis severity in patients with nonalcoholic fatty liver disease and type 2 diabetes"],"prefix":"10.1002","volume":"10","author":[{"given":"Asieh","family":"Mansour","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences  Tehran 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