{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:51:12Z","timestamp":1789818672976,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate for correlation between intraoperative ultrasound (IOUS)\u2010measured tumor thickness (TT) (uTT) and histopathological TT (hTT), and to compare IOUS\u2010assisted resection with conventional resection in patients with oral tongue cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Ovid MEDLINE (1946\u20102023), <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Embase.com\">Embase.com<\/jats:ext-link> (1947\u20102023), and Web of Science (All Databases 1900\u20102023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Inclusion criteria were the use of IOUS for the management of oral tongue cancer. Studies that did not report quantitative data were excluded. Additionally, studies that were not contributory to meta\u2010analysis, or a narrative analysis of pooled results were excluded. Selection was carried out by 2 reviewers. A total of 2417 studies were initially identified, with 12 ultimately being included in this review, and 7 included in the meta\u2010analysis. Data were extracted by 2 investigators and were pooled using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our meta\u2010analysis reveals a pooled correlation coefficient of 0.92 (95% confidence interval: 0.80\u20100.96) for studies comparing uTT to hTT. Studies comparing IOUS\u2010assisted resection to conventional resection found IOUS\u2010assisted resection yielded wider nearest margins in all studies reporting this outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IOUS reliably measures TT, similarly to that of histopathology measurement. IOUS\u2010assisted resection, which allows the surgeon to view the deep extent of tumor invasion, may increase closest radial margin distance compared to conventional resection. IOUS\u2010assisted resection may represent a more reliable approach to achieving clear margins than conventional resection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.147","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:35:04Z","timestamp":1717655704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intraoperative Ultrasound for the Management of Oral Tongue Cancer: a Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-8564","authenticated-orcid":false,"given":"Ryland N.","family":"Spence","sequence":"first","affiliation":[{"name":"The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne H.","family":"Au","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and 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