{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:49:06Z","timestamp":1792986546211,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Investigate multilevel radiofrequency ablation (RFA) as an alternative therapy for patients with mild\u2010to\u2010moderate obstructive sleep apnea (OSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, open\u2010label, single\u2010arm, nonrandomized clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multicenter academic and private clinics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with mild\u2010to\u2010moderate OSA (apnea\u2010hypopnea index\u00a0[AHI] 10\u201030; body mass index\u2009\u2264\u200932) were treated with 3 sessions of office\u2010based RFA to the soft palate and tongue base. The primary outcome was a change in the AHI\u00a0and oxygen desaturation index (ODI 4%). Secondary outcomes included subjective sleepiness level; snoring level; and sleep\u2010related quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six patients were enrolled, with 43 (77%) completing the study protocol. Following 3 sessions of office\u2010based RFA to the palate and base of the tongue, the mean AHI decreased from 19.7 to 9.9 (<jats:italic>p<\/jats:italic>\u2009=\u2009.001), while the mean ODI (4%) decreased from 12.8 to 8.4 (<jats:italic>p<\/jats:italic>\u2009=\u2009.005). Mean Epworth Sleepiness Scale\u00a0scores declined from 11.2 (\u00b15.4) to 6.0 (\u00b13.5) (<jats:italic>p<\/jats:italic>\u2009=\u2009.001), while Functional Outcomes of Sleep Questionnaire scores improved from a mean of 14.9 at baseline to 17.4 (<jats:italic>p<\/jats:italic>\u2009=\u2009.001). The mean visual analog scale snoring scale was reduced from 5.3 (\u00b11.4) at baseline to 3.4 (\u00b11.6) at 6 months posttherapy (<jats:italic>p<\/jats:italic>\u2009=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Office\u2010based, multilevel RFA of the soft palate and base of the tongue is a safe and effective treatment option with minimal morbidity for properly selected patients with mild\u2010to\u2010moderate OSA who are intolerant or refuse continuous positive airway pressure therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.19","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T15:48:11Z","timestamp":1676648891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Office\u2010Based Multilevel Radiofrequency Ablation for Mild\u2010to\u2010Moderate Obstructive Sleep 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