{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:40:26Z","timestamp":1760956826323,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":86,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Adipose stem cells (ASCs) have been shown in many preclinical studies to be potent suppressors of the immune system. Prior studies suggest that ASCs may promote cancer progression and wound healing. However, clinical studies investigating the effects of native, or fat\u2010grafted adipose tissue on cancer recurrence have generated mixed results. We investigated whether adipose content in reconstructive free flaps for oral squamous cell carcinoma (OSCC) is associated with disease recurrence and\/or reduction in wound complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a review of 55 patients undergoing free flap reconstruction for OSCC over a 14\u2010month period. Using texture analysis software, we measured the relative free flap fat volume (FFFV) in postoperative computed tomography scans and compared fat volume with patient survival, recurrence, and wound healing complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report no difference in mean FFFV between patients with or without recurrence: 13.47\u2009cm<jats:sup>3<\/jats:sup> in cancer\u2010free survivors and 17.99\u2009cm<jats:sup>3<\/jats:sup> in cases that recurred (<jats:italic>p<\/jats:italic>\u2009=\u2009.56). Two\u2010year recurrence\u2010free survival in patients with high and low FFFV was 61.0% and 59.1%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.917). Although only 9 patients had wound healing complications, we found no trend in the incidence of wound healing complications between patients with high versus low FFFV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FFFV is not associated with recurrence or wound healing in patients undergoing free flap reconstruction for OSCC, suggesting adipose content should not be of concern to the reconstructive surgeon.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.46","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T05:35:25Z","timestamp":1679981725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Free Flap Fat Volume is Not Associated With Recurrence or Wound Complications in Oral Cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Andre J.","family":"Burnham","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Wicks","sequence":"additional","affiliation":[{"name":"Department of Radiology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen L.","family":"Baugnon","sequence":"additional","affiliation":[{"name":"Department of Radiology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Head and Neck Program Winship Cancer Institute at Emory University  Georgia Atlanta USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W.","family":"El\u2010Deiry","sequence":"additional","affiliation":[{"name":"Head and Neck Program Winship Cancer Institute at Emory University  Georgia Atlanta USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-3531","authenticated-orcid":false,"given":"Nicole C.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Head and Neck Program Winship Cancer Institute at Emory University  Georgia Atlanta USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0289"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-02-0105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2019.0851"},{"issue":"661","key":"e_1_2_9_5_1","article-title":"Paracrine anti\u2010inflammatory effects of adipose tissue\u2010derived mesenchymal stem cells in human monocytes","volume":"9","author":"Guill\u00e9n MI","year":"2018","journal-title":"Front 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