{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:26:47Z","timestamp":1788535607881,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the efficacy of office\u2010based blue laser therapy for vocal fold leukoplakia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of patients with vocal fold leukoplakia who underwent office\u2010based blue laser therapy between July 2019 and October 2022 was conducted. The video recordings of their laryngeal examination and their voice evaluation were analyzed before and after surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 patients, eight with unilateral disease and 2 with bilateral disease, were included in this study. In total, 12 vocal folds with leukoplakia were treated. Nine had a single session and 3 had 2 sessions due to incomplete regression of the lesion after the first laser therapy session. Following treatment, 9 regressed completely (75%) and 3 regressed partially (25%). The mean Voice Handicap Index\u201010 (VHI\u201010) score decreased significantly from 15.4\u2009\u00b1\u200912.9 preoperatively to 3.8\u2009\u00b1\u20092.86 after surgery (<jats:italic>p<\/jats:italic>\u2009=\u2009.023). There was a statistically significant decrease in the means of grade, roughness, breathiness, asthenia, and strain (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). There was also a statistically significant decrease in the jitter and shimmer percent (<jats:italic>p<\/jats:italic>\u2009=\u2009.008 and <jats:italic>p<\/jats:italic>\u2009=\u2009.048, respectively) and a significant increase in the maximum phonation time from 9.63\u2009\u00b1\u20093.83\u00a0to 13.54\u2009\u00b1\u20095.92\u2009seconds (<jats:italic>p<\/jats:italic>\u2009=\u2009.039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This preliminary study indicates that office\u2010based blue laser therapy is an effective treatment modality for vocal fold leukoplakia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.59","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:01:10Z","timestamp":1686873670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Office\u2010Based Blue Laser Therapy for Vocal Fold Leukoplakia: A Preliminary Report of 12 Cases"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-3568","authenticated-orcid":false,"given":"Abdul\u2010Latif","family":"Hamdan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-3619","authenticated-orcid":false,"given":"Anthony","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-1289","authenticated-orcid":false,"given":"Patrick","family":"Abou Raji Feghali","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-3486","authenticated-orcid":false,"given":"Jad","family":"Hosri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-0066","authenticated-orcid":false,"given":"Christophe","family":"Abi Zeid Daou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1619-2898","authenticated-orcid":false,"given":"Samer","family":"Abou\u2010Rizk","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery Lebanese American University Medical Center\u2010Rizk Hospital Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880130604"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21432"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24214"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700114"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03111.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2010.02181.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.04.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000902"},{"issue":"10","key":"e_1_2_10_11_1","first-page":"18265","article-title":"Comparison of CO2 laser and conventional laryngomicrosurgery treatments of polyp and leukoplakia of the vocal fold","volume":"8","author":"Zhang Y","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209691"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.041"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500905"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-4974-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320960544"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2021.03.031"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00009"},{"key":"e_1_2_10_20_1","first-page":"83","volume-title":"Clinical Examination of Voice","author":"Hirano M","year":"1981"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199907000-00032"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26445"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.4129"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894081170S701"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29370"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.59","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:57:49Z","timestamp":1760961469000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/oto2.59"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/oto2.59"],"URL":"https:\/\/doi.org\/10.1002\/oto2.59","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"value":"2473-974X","type":"print"},{"value":"2473-974X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"2023-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e59"}}