{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:47:59Z","timestamp":1768927679489,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to compare the effectiveness of 2 artificial saliva substitutes (Biot\u00e8ne vs HydraSmile) in the symptomatic management of radiation\u2010induced xerostomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Randomized double\u2010blind cross\u2010over study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single tertiary care academic institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included adult patients 6 months postradiotherapy (50\u201070\u2009gy) for squamous cell carcinoma of the oral cavity, oropharynx, or larynx. The primary endpoint was change in overall subjective xerostomia score from baseline, through use of HydraSmile versus Biot\u00e8ne. Scores were derived from a 100\u2010point visual analog scale, with higher scores indicating better symptomatic control. Analysis of covariance model was used to regress the difference in after\u2010treatment measurement between HydraSmile and Biot\u00e8ne, with respect to baseline differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 91 participants were included (mean age 63.0 years [SD 9.7]; 85.7% male; 97.8% White). Change in overall xerostomia score with respect to baseline was not significantly different between HydraSmile and Biot\u00e8ne (mean difference 1.24, 95% confidence interval [CI] \u22122.35 to 4.81). Compared to water alone, both HydraSmile (mean difference 7.45, 95% CI 3.61\u201011.29) and Biot\u00e8ne (mean difference 7.24, 95% CI 3.06\u201011.43) significantly improved overall xerostomia score. Forty (44%) patients reported a preference for Biot\u00e8ne, 46 (50.5%) preferred HydraSmile, and 5 (5.5%) had no preference. Patients who preferred Biot\u00e8ne did not significantly benefit from HydraSmile, whereas those who preferred HydraSmile did not significantly benefit from Biot\u00e8ne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Biot\u00e8ne and HydraSmile significantly improved oral dryness among patients with radiation\u2010induced xerostomia. While neither product demonstrated treatment superiority, individual product preference was predictive of greatest treatment benefit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.70038","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T07:49:24Z","timestamp":1735890564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biot\u00e8ne Versus HydraSmile for Radiation\u2010Induced Xerostomia: Randomized Double\u2010Blind Cross\u2010Over Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-5366","authenticated-orcid":false,"given":"Randall J.","family":"Harley","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Bowers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Pittsburgh, Graduate School of Public Health Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikayla","family":"Bisignani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-668X","authenticated-orcid":false,"given":"Marci L.","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"},{"name":"Department of Acute and Tertiary Care University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas T.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20456"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21157"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0827-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.021"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23699"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.1992.tb00401.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgz016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133199"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2005.00587.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050286"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.08.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-020-00630-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14475"},{"key":"e_1_2_8_16_1","unstructured":"ShenD LuZ.Estimate Carryover Effect in Clinical Trial Crossover Designs. 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