{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:28:58Z","timestamp":1761006538624,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Children post\u2010tracheoesophageal fistula (TEF) repair may present with chronic respiratory and gastrointestinal symptoms that can affect quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify factors associated with positive findings on triple endoscopy following neonatal TEF repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with retrospective review of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care center aerodigestive program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children with neonatally repaired congenital TEF who had a triple endoscopy between 2011 and 2022 were reviewed. The presence of chronic cough, recurrent pulmonary infections, lipid\u2010laden macrophages (LLM), and airway and esophageal anomalies were among the variables analyzed. Chi\u2010square and Kruskal\u2010Wallis univariate analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 4.28\u2009\u00b1\u20094.65 years old, and the most common type of TEF repaired was type C (78%). Within our cohort, 87% of patients had GERD, 60% of patients had prior esophageal dilations, and 84% of patients had tracheomalacia. Thirty\u2010one (46.3%) patients had laryngeal cleft, of which 77.4% had a history of prior esophageal dilations (<jats:italic>P<\/jats:italic>\u2009=\u2009.01). Twenty\u2010one (33.9%) patients had tracheal diverticulum on bronchoscopy, which was associated with chronic cough, stridor, and coughing with feeds. Patients with positive LLM on BAL were associated with presentation of chronic cough and stridor (<jats:italic>P<\/jats:italic>\u2009=\u2009.03). Recurrent TEF was associated with chronic cough. Subglottic stenosis was associated with a history of prolonged intubation (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic cough was frequently reported and associated with tracheal diverticulum, recurrent TEF, and positive LLM findings on triple endoscopy in patients after congenital TEF repair. Patients presenting with chronic cough and stridor following congenital TEF repair may benefit from a multidisciplinary evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.70059","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T07:49:48Z","timestamp":1735890588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aerodigestive Sequelae and Triple Endoscopy after Congenital Tracheoesophageal Fistula Repair in Children"],"prefix":"10.1002","volume":"9","author":[{"given":"Whitney","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology Texas Children's Hospital Houston Texas USA"},{"name":"Bobby R. Alford Department of Otolaryngology\u2013Head and Neck Surgery Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric H.","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition Texas Children's Hospital, Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailendra","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonary Medicine Texas Children's Hospital, Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen E.","family":"Hosek","sequence":"additional","affiliation":[{"name":"Department of Surgery Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-2023","authenticated-orcid":false,"given":"Elton M.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology Texas Children's Hospital Houston Texas USA"},{"name":"Bobby R. Alford Department of Otolaryngology\u2013Head and Neck Surgery Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.11.046"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1121803"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-017-0396-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29798"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0218-2020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00120"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.12.025"},{"issue":"4","key":"e_1_2_8_9_1","first-page":"310","article-title":"Long\u2010term esophageal and respiratory outcomes in children with esophageal atresia and tracheoesophageal fistula","volume":"4","author":"Cartabuke RH","year":"2016","journal-title":"Gastroenterol Rep (Oxf)"},{"issue":"3","key":"e_1_2_8_10_1","article-title":"Atresia of the esophagus","volume":"74","author":"Gross RE","year":"1947","journal-title":"Am J Dis Child"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00382-2019"},{"volume-title":"Principles and Practice of Interventional Pulmonology","year":"2012","author":"Stanzel F","key":"e_1_2_8_12_1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.10.023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/oto2.33"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.10.024"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12977"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000849"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:28:58Z","timestamp":1760952538000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/oto2.70059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/oto2.70059"],"URL":"https:\/\/doi.org\/10.1002\/oto2.70059","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"type":"print","value":"2473-974X"},{"type":"electronic","value":"2473-974X"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70059"}}