{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:21:47Z","timestamp":1782321707779,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to characterize concurrent nasal symptoms in a cohort of patients with non\u2010rhinogenic headache (NRH) presenting to an otolaryngology clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single tertiary care institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with NRH were recruited over a 2\u2010year period (February 2021 to February 2023). Patients were eligible if they endorsed midfacial pain or pressure for at least 10 days a month over the previous 3 months and had no evidence of rhinosinusitis on both nasal endoscopy and computed tomography imaging. Study participants used a mobile application to keep a daily log of their facial pain\/pressure, nasal congestion, and nasal mucus\/discharge. Symptom severity was scored on a scale from 1 (none) to 10 (worst) for 30 consecutive days. Repeated measures correlation coefficients were calculated to evaluate overall or common intra\u2010individual association for each symptom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight patients were enrolled, and they completed the 30\u2010day symptom log. Median (range) scores were 5 (1\u201010), 4 (1\u201010), and 2 (1\u201010) for facial pain\/pressure, congestion, and mucus, respectively. Patients had significant day\u2010to\u2010day fluctuations in scores for all 3 symptoms, with a significant positive correlation between symptoms: congestion\/mucus (<jats:italic>r<\/jats:italic>\u2009=\u20090.74181, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), congestion\/facial pain (<jats:italic>r<\/jats:italic>\u2009=\u20090.5873, <jats:italic>P<\/jats:italic>\u2009=\u2009.001), and mucus\/facial pain (<jats:italic>r<\/jats:italic>\u2009=\u20090.49384, <jats:italic>P<\/jats:italic>\u2009=\u2009.0076).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with NRH often have concurrent nasal symptoms. Moreover, nasal congestion, mucus, and facial pain\/pressure had significant correlations in day\u2010to\u2010day fluctuations in severity. Our findings suggest the possibility that all three symptoms share a common pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.70083","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T06:24:43Z","timestamp":1737959083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concurrent Nasal Symptoms in Non\u2010Rhinogenic Headache"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-7174","authenticated-orcid":false,"given":"David W.","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery and Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-4930","authenticated-orcid":false,"given":"Avivah J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Abi","family":"Hachem","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Witsell","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Frederick","family":"Godley","sequence":"additional","affiliation":[{"name":"University Otolaryngology Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00688.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.16.1769"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmv019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29588"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818764387"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4065\/80.7.908"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-004-0025-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114000929"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1036798"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02610-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413512031"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21654"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22790"}],"container-title":["OTO 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