{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:37:24Z","timestamp":1784569044321,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fibrin sealants (FS) are gaining popularity in surgical practice. However, limited data exist for most facial plastic surgical (FPS) procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The TriNetX Research Network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The TriNetX national database was utilized to identify patients that underwent select FPS procedures. Cohorts included one group with FS recorded on the same day as the procedure, and another without. Demographics, comorbidities, and postoperative complications were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 550,777 patients underwent an FPS procedure, 600 patients with FS and 550,177 without. There was no difference in the rate of overall complications between groups (adjusted odds ratio [aOR] 0.92, [0.71\u20101.2], <jats:italic>P<\/jats:italic>\u2009=\u2009.54), with adjustment for age, race, ethnicity, marital status, nicotine use, and anticoagulation. However, higher rates of postoperative wound disruption (aOR 1.63, [1.14\u20102.33], <jats:italic>P<\/jats:italic>\u2009=\u2009.008) were seen in the FS group. Patients in the FS group had higher rates of nicotine use (12.7% vs 8.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and anticoagulation (39.2% vs 27.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) overall. Subanalyses by procedure found increased rates of any postoperative complications for those with FS (aOR 1.51, [1.01\u20102.24], <jats:italic>P<\/jats:italic>\u2009=\u2009.044) in patients receiving regional flaps. There were no significant differences in postoperative complications between groups in patients receiving grafts, rhinoplasty, or rhytidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were no differences in the rates of having any complications between groups overall. Patients receiving regional flaps and grafts experienced more complications. There were no significant differences between groups in patients receiving grafts, rhinoplasty, or rhytidectomy. Surgeons may consider utilizing FS for FPS procedures when appropriate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.70102","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T03:37:12Z","timestamp":1743219432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fibrin Sealants in Facial Plastic Surgery: A National Database Analysis of Complication Risk"],"prefix":"10.1002","volume":"9","author":[{"given":"H\u00e4nel W.","family":"Eberly","sequence":"first","affiliation":[{"name":"Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Medical Center Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao Y.","family":"Sciscent","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya S.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Penn State College of Medicine Hershey Pennsylvania USA"},{"name":"Sarasota Memorial Hospital Research Institute Sarasota Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-5059","authenticated-orcid":false,"given":"Jessyka G.","family":"Lighthall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Penn State Milton S. Hershey Medical Center and Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2016.02.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2020.06.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2014.01.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/203943"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(94)90087-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199112000-00009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05861-8"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"68","article-title":"The ideal tissue adhesive in facial plastic and reconstructive surgery","volume":"19","author":"Ellis DA","year":"1990","journal-title":"J Otolaryngol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599237"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000097291.15196.78"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X13479969"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2022.0160"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00044"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31816673f8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000278092.28351.c9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.2008.511"},{"issue":"2","key":"e_1_2_8_18_1","first-page":"21","article-title":"Artiss\u00ae and burn treatment: a retrospective analysis contributing to current clinical practice","volume":"10","author":"Van Kerckhoven L","year":"2020","journal-title":"Int J Burns Trauma"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12837"},{"key":"e_1_2_8_20_1","unstructured":"ASPS procedural statistics release. ASPS. September 26 2023. Accessed March 21 2024.https:\/\/www.plasticsurgery.org\/documents\/News\/Statistics\/2022\/plastic-surgery-statistics-report-2022.pdf"},{"key":"e_1_2_8_21_1","article-title":"Risks and complications in rhinoplasty","volume":"6","author":"Rettinger G","year":"2007","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-017-1039-0"},{"key":"e_1_2_8_23_1","first-page":"1","article-title":"Tissue adhesives in otorhinolaryngology","volume":"8","author":"Schneider G","year":"2009","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31912"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-024-03908-3"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:28:41Z","timestamp":1760952521000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/oto2.70102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/oto2.70102"],"URL":"https:\/\/doi.org\/10.1002\/oto2.70102","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"value":"2473-974X","type":"print"},{"value":"2473-974X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70102"}}