{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:29:34Z","timestamp":1761006574706,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>With more than 1.57 billion people affected by hearing loss worldwide, this study investigates the association between ototoxic drug use and hearing loss, utilizing South Korean national health data. The goal is to inform clinical prevention and management guidelines by identifying ototoxic drugs and assessing their risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This study is a retrospective observational study using the Health Insurance Review and Assessment Service (HIRA) to analyze the association between suspected ototoxic drug use and hearing loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Data were obtained from the National Patient Samples (NPS) of HIRA in South Korea, covering 2009 to 2016. The study included all National Health Insurance (NHI) enrollees with at least one hospital visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with suspected ototoxicity hearing loss (SOHL) were identified, and ototoxic drugs were reviewed using national data. Of 491 reviewed ingredients, 151 were suspected ototoxic. Logistic regression and Cox proportional hazards models assessed associations between drug prescriptions and SOHL, analyzed with SAS 9.4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SOHL patients were older, with higher rates of underlying conditions and medication use compared to controls. The odds ratio (OR) for SOHL was significantly elevated in patients aged \u226565, increasing from 3.007 to 3.366. Proton pump inhibitors (PPIs) and antibiotics presented elevated risks, especially in older adults, with hazard ratios (HRs) for PPIs rising from 1.85 to 2.90. Notably, PPIs posed higher risks for patients &lt;65.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study confirms that factors like age, gender, underlying diseases, and specific medications increase SOHL risk, emphasizing the need for cautious medication use tailored to age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.70121","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:45:51Z","timestamp":1745567151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Review of Ototoxic Drugs Using Health Insurance Data: A Data\u2010Driven Management System"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0673-7505","authenticated-orcid":false,"given":"Jiwon","family":"Kim","sequence":"first","affiliation":[{"name":"Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine Wonju South Korea"},{"name":"Department of Medical Informatics and Biostatistics Yonsei University Wonju College of Medicine Wonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0162-1741","authenticated-orcid":false,"given":"Chul Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine Wonju South Korea"},{"name":"Department of Medical Informatics and Biostatistics Yonsei University Wonju College of Medicine Wonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-5312","authenticated-orcid":false,"given":"Junhun","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine Wonju South Korea"},{"name":"Department of Medical Informatics and Biostatistics Yonsei University Wonju College of Medicine Wonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-4676","authenticated-orcid":false,"given":"Young Joon","family":"Seo","sequence":"additional","affiliation":[{"name":"Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine Wonju South Korea"},{"name":"Department of Otorhinolaryngology Yonsei University Wonju College of Medicine Wonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00516-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz166"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-72561-1_8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.725566"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000001292"},{"issue":"6","key":"e_1_2_10_7_1","first-page":"601","article-title":"Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide","volume":"15","author":"Cianfrone G","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2478"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.5.718"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb43010012"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-023-03534-z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15210"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"1039","article-title":"The risk factors for age\u2010related hearing loss: an integrative review","volume":"3","author":"Joo Y","year":"2016","journal-title":"Ann Gerontol Geriatr Res"},{"key":"e_1_2_10_14_1","unstructured":"D. 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