{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:41:20Z","timestamp":1773009680357,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":70,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sinus headache is a common complaint that can be due to chronic rhinosinusitis (CRS) or non\u2010rhinogenic facial pain\/pressure (NRFP). The purpose of this study is to characterize over\u2010the\u2010counter (OTC) medications used for sinus headache.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care academic center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients presenting with midfacial pain or pressure to a rhinology clinic were surveyed on how often they utilized common OTC medications, with choices ranging from \u201calways\u201d to \u201cnever.\u201d Patients were categorized into CRS or NRFP groups based on endoscopy and imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 251 patients, with 69.3% female and a mean (standard deviation) age of 49.9 (15.7) years. Patients with CRS (n\u2009=\u2009114) reported symptom relief \u201csometimes\u201d to \u201calways\u201d when using pain relievers (38.6%), intranasal steroids (37.7%), and oral antihistamines (36%). Patients with NRFP (n\u2009=\u2009137) responded \u201csometimes\u201d to \u201calways\u201d with the use of intranasal steroids (49.6%), decongestants (48.9%), and pain relievers (45.3%). A greater proportion of NRFP patients responded \u201csometimes\u201d to \u201calways\u201d for decongestants to relieve symptoms compared to CRS patients (<jats:italic>P<\/jats:italic>\u2009=\u2009.011). There was no significant difference in other OTC medications between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with midfacial pain or pressure reported using a variety of OTC medications for symptomatic relief. Decongestants were more frequently associated with symptom improvement in patients with NRFP. This finding indicates that symptomatic relief with decongestants may suggest a diagnosis of NRFP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.70161","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T12:04:14Z","timestamp":1757419454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Over\u2010the\u2010Counter Medications for Sinus Headache: A Cross\u2010Sectional Survey Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5141-6253","authenticated-orcid":false,"given":"Nathan Gabriel","family":"Sattah","sequence":"first","affiliation":[{"name":"School of Medicine Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Jie","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Coles","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Frederick","family":"Godley","sequence":"additional","affiliation":[{"name":"University Otolaryngology Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley J.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery &amp; Communication Sciences Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph Abi","family":"Hachem","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery &amp; Communication Sciences Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-7174","authenticated-orcid":false,"given":"David W.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery &amp; Communication Sciences Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00688.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000779"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.16.1769"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinpr.2023.100230"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.18787\/jr.2024.00023"},{"issue":"10","key":"e_1_2_8_7_1","first-page":"247","article-title":"Patient adherence to allergic rhinitis treatment: results from patient surveys","volume":"10","author":"Valovirta E","year":"2008","journal-title":"Medscape J Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28366"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/oto2.70083"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22790"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0984-1"},{"issue":"6","key":"e_1_2_8_13_1","first-page":"110S","article-title":"The pharmacology of alpha\u2010adrenergic decongestants","volume":"13","author":"Johnson DA","year":"1993","journal-title":"Pharmacotherapy"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114000929"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818764387"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.644"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22216"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420956530"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:40:06Z","timestamp":1760971206000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/oto2.70161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/oto2.70161"],"URL":"https:\/\/doi.org\/10.1002\/oto2.70161","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"value":"2473-974X","type":"print"},{"value":"2473-974X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70161"}}