{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:26:34Z","timestamp":1791501994966,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence and odds ratios for benign paroxysmal positional vertigo and other dizziness conditions in hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Analytical cross\u2010sectional study from January 1, 2018, through December 31, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single\u2010institution tertiary care center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with primary or secondary hyperparathyroidism were analyzed through a population\u2010based sample using ICD\u201010 diagnostic codes. The primary outcome included prevalence rates for benign paroxysmal positional vertigo and other dizziness conditions in primary and secondary hyperparathyroidism. Secondary outcomes consisted of odds ratios for benign paroxysmal positional vertigo and other dizziness conditions in primary versus secondary hyperparathyroidism, and with further systemic calcium dysregulation in the setting of vitamin D deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      839 primary hyperparathyroidism and 1418 secondary hyperparathyroidism subjects were included. The prevalence of benign paroxysmal positional vertigo was 35.76 per 100 individuals in primary hyperparathyroidism, higher than in the general population (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.01). Collectively, dizziness conditions were diagnosed as frequently in hyperparathyroidism as nephrolithiasis. The prevalence of benign paroxysmal positional vertigo did not statistically vary in secondary hyperparathyroidism from the general population, however, unspecified dizziness diagnoses were far more common than in primary hyperparathyroidism (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.006). Benign paroxysmal positional vertigo and other dizziness conditions were more likely in subjects with vitamin D deficiency diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism is a risk factor for vertigo\/benign paroxysmal positional vertigo. Hyperparathyroidism, both in primary and secondary disease, may be disruptive to otoconia. Further research is needed to understand this relationship. Improved understanding of risk factors for benign paroxysmal positional vertigo offers additional insight into the pathophysiologic mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oto2.70209","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:59:48Z","timestamp":1773723588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hyperparathyroidism and Dizziness: An Epidemiological Assessment"],"prefix":"10.1002","volume":"10","author":[{"given":"Mohsin","family":"Mirza","sequence":"first","affiliation":[{"name":"University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"McClure","sequence":"additional","affiliation":[{"name":"University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-6019","authenticated-orcid":false,"given":"Kourosh","family":"Parham","sequence":"additional","affiliation":[{"name":"University of Connecticut School of Medicine Farmington Connecticut USA"},{"name":"Division of Otolaryngology\u2212Head &amp; Neck Surgery University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/835671"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00136"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5287-z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0149-2"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"160","article-title":"How common are various causes of dizziness? A critical review","volume":"93","author":"Kroenke K","year":"2000","journal-title":"South Med J"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7190-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7913-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2013.10.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.129"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.100420"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03743.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.04.053"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.01.074"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00003.2004"},{"key":"e_1_2_7_16_1","first-page":"26","article-title":"Calcium ion uptake and exchange in otoconia","volume":"25","author":"Ross MD","year":"1979","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6712-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.8840192"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008366"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345016.33983.e0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24162"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.04.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26628"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00404"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001534"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2016.2640"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5146-6"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.03.005"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/89.12.921"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301895"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02483"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1415"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2009.00581.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.07.013"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","unstructured":"SlatopolskyE.The role of calcium phosphorus and vitamin D metabolism in the development of secondary hyperparathyroidism.Nephrol Dial Transplant. 1998;13(Suppl 3):3\u20108.","DOI":"10.1093\/ndt\/13.suppl_3.3"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2011.01093.x"},{"issue":"14","key":"e_1_2_7_38_1","first-page":"1057","article-title":"[Misdiagnosis and associated costs of benign paroxysmal positional vertigo]","volume":"97","author":"Qian SX","year":"2017","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331046"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3160"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0569"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70257-3"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00201-8"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010343"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/audiolres12040045"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16050689"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211004245"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137931"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489709113434"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-018-0666-8"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2020.02.013"},{"issue":"1","key":"e_1_2_7_52_1","first-page":"1","article-title":"Effect of defective calcium metabolism on otolith formation in zebrafish","volume":"7","author":"Iwamoto A","year":"2024","journal-title":"Med Sci & Innov"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.2113\/0540249"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092420216"},{"issue":"4","key":"e_1_2_7_55_1","article-title":"Genes, manganese, and zinc in formation of otoconia: labeling, recovery, and maternal effects","volume":"1986","author":"Erway L","year":"1986","journal-title":"Scanning Electron Microsc"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14308"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012765"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14101279"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.950023"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/21695717.2023.2213957"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.109982"},{"key":"e_1_2_7_62_1","first-page":"67","volume-title":"Handbook of Clinical Neurology","author":"Neuhauser HK","year":"2016"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oto2.70209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:57:54Z","timestamp":1779724674000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/oto2.70209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/oto2.70209"],"URL":"https:\/\/doi.org\/10.1002\/oto2.70209","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"value":"2473-974X","type":"print"},{"value":"2473-974X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70209"}}