{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:05:43Z","timestamp":1779725143748,"version":"3.53.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is a prevalent pediatric disorder that, if untreated, can result in substantial developmental and health consequences. Tongue reduction procedures, such as midline posterior glossectomy (MPG), are increasingly used to address tongue base obstruction. This systematic review evaluates the effectiveness and safety of tongue reduction procedures for pediatric OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Embase, PubMed, and Web of Science databases were queried for studies from inception to September 20, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Studies reporting on outcomes of pediatric patients (\u226421 years) undergoing tongue reduction surgery for OSA were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 477 abstracts, 9 studies met the inclusion criteria, representing 146 pediatric patients. Surgical techniques included MPG, transoral robotic\u2010assisted tongue base resection, and keyhole partial glossectomy. Primary outcomes assessed were apnea\u2010hypopnea index (AHI), minimum oxygen saturation, and adverse events. All studies reported a reduction in AHI and increased minimum oxygen saturation following tongue reduction despite the method. Adverse events appear to be rare but included postoperative bleeding, need for reintubation, and wound dehiscence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tongue reduction procedures appear to be safe and effective for managing pediatric OSA, improving key clinical outcomes. However, long\u2010term results, comparative studies of surgical techniques, and refined patient selection criteria are needed. Future research should also identify risk factors for persistent OSA following tongue base reduction. These findings suggest that tongue reduction is a valuable addition to the treatment arsenal for pediatric OSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oto2.70215","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:26:06Z","timestamp":1773008766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tongue Reduction for Pediatric Obstructive Sleep Apnea: A Systematic Review"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-5362","authenticated-orcid":false,"suffix":"IV","given":"Adrian","family":"Williamson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, College of Medicine University of Arkansas for Medical Sciences Little Rock Arkansas USA"},{"name":"Division of Pediatric Otolaryngology Arkansas Children's Hospital Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6313-205X","authenticated-orcid":false,"given":"Rohit","family":"Nallani","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology Children's Mercy Hospital Kansas City Missouri USA"},{"name":"Department of Otolaryngology\u2013Head and Neck surgery University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6568-5491","authenticated-orcid":false,"given":"Jason R.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology Children's Mercy Hospital Kansas City Missouri USA"},{"name":"Division of Pediatric Otolaryngology, School of Medicine University of Missouri\u2013Kansas City Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.6.731"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4852"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16183235"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.24911\/IJMDC.51-1701581085"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1671"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-138MG"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.07.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.3.554"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1969"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.10.020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.03.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.091132"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.120603"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.11.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818807917"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.033"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.01.043"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.08.067"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.04.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000006673"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199703000-00004"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.109810"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4269-x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221094211"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811409837"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.159"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818815683"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25459"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.02.030"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.1067"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26174"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4545-4"},{"issue":"1","key":"e_1_2_10_34_1","first-page":"37","article-title":"Hypoglossal nerve stimulation in adolescents with down syndrome and obstructive sleep apnea","volume":"144","author":"Diercks GR","year":"2017","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2021.110868"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_37_1","unstructured":"Covidence.www.covidence.org"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045899"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08252-x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500809"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.10.010"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26104"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1685156"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221094211"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000489"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1930OC"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2003.08.007"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.11.006"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102566"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.339"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820985000"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.10.006"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2023.111627"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2023.111748"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oto2.70215","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:58:15Z","timestamp":1779724695000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/oto2.70215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/oto2.70215"],"URL":"https:\/\/doi.org\/10.1002\/oto2.70215","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"value":"2473-974X","type":"print"},{"value":"2473-974X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70215"}}