{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:34:11Z","timestamp":1787762051949,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients diagnosed with de novo sinonasal squamous cell carcinoma (DN\u2010SSCC) generally present at an advanced stage and have a poor prognosis. The study aimed to summarize and analyze the outcomes of DN\u2010SSCC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single\u2010center clinical database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Overall survival was assessed with Kaplan\u2010Meier analyses and Cox proportional hazard regression analyses for patients diagnosed with DN\u2010SSCC between 2010 and 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Long\u2010term follow\u2010up was completed for 85 out of 112 patients. The distribution of cancer stages was as follows: 1.8% in stage \u2160, 7.1% in stage \u2161, 23.2% in stage \u2162, and 67.9% in stage \u2163. Ocular invasion was present in 50.9% and intracranial invasion in 23.2%. Significant intergroup differences in T\u2010stage (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.009) and clinical stages (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.028) across therapeutic modalities. The 1\u2010year and 5\u2010year overall survival (OS) rates were 83.5% and 51.4%, respectively. Factors significantly associated with prognosis included age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.048), lymph node classification (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.003), clinical stages (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002), ocular invasion (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.035), therapeutic modalities (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and resection margin status (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.005). Surgery followed by adjuvant chemotherapy or\/and radiotherapy (Surgery\u2009+\u2009CT\/RT) demonstrated best prognosis, with a 5\u2010year OS rate of 71.9%. Margin status significantly impacted survival outcomes (5\u2010year OS: 56.0% negative margin versus 29.0% positive margin) (log\u2010rank\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.005). Lymph node classification (HR 4.927, 95% CI 1.296\u201018.733;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.019) and preoperative induction chemotherapy combined with surgery (ICT\u2009+\u2009Surgery) (HR 0.048, 95% CI 0.004\u20100.574;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.017) were independent prognostic factors for DN\u2010SSCC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients receiving Surgery\u2009+\u2009CT\/RT had better prognoses. This therapeutic modality is recommended for advanced\u2010stage patients, especially those with positive resection margins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oto2.70226","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:47:26Z","timestamp":1774565246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Determinants in De Novo Sinonasal Squamous Cell Carcinoma: A Retrospective Study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3823-2714","authenticated-orcid":false,"given":"Yue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Key Laboratory of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Key Laboratory of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Key Laboratory of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Key Laboratory of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-2647","authenticated-orcid":false,"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Key Laboratory of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25465"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21830"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0692-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22556"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420939422"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-07057-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.104512"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.07.741"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33452"},{"key":"e_1_2_10_12_1","unstructured":"AminMB EdgeSB GreeneFL et al. eds. 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