{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:45Z","timestamp":1787762025377,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether the proportion of resected thyroid tissue or the residual lobe volume predicts postoperative hypothyroidism following hemithyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Multicenter retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Ziv Medical Center and Galilee Medical Center, Israel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 134 adult patients who underwent hemithyroidectomy between 2017 and 2024. Patients with preexisting hypothyroidism or malignant histopathology were excluded. Preoperative thyroid gland volumes were measured by computed tomography (CT) and correlated with serum thyroid hormone profiles (T3, T4, and TSH) obtained preoperatively, and at 1 and 6 months postoperatively. Associations between thyroid volume parameters and postoperative hypothyroidism were analyzed statistically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Postoperative hypothyroidism developed in 29.1% of patients, within the first postoperative month. Affected patients exhibited significantly higher baseline TSH levels than euthyroid counterparts (3.0 vs 1.4\u2009\u03bcIU\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). No significant correlation was found between postoperative thyroid function and total gland volume, resected lobe volume, or residual\u2010to\u2010total volume ratio. At 6 months, only 12% of patients remained hypothyroid, suggesting partial recovery of thyroid function in the remaining lobe.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neither the extent of resection nor the residual thyroid volume predicted postoperative hypothyroidism. These findings imply that factors beyond gland size\u2014such as preoperative functional reserve or intrinsic thyroid health\u2014may play a more decisive role in maintaining postoperative endocrine stability. Identifying these predictors could enhance patient selection, risk stratification, and postoperative follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oto2.70239","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:51:04Z","timestamp":1777283464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Thyroid Gland Volume and Postoperative Hypothyroidism Following Hemithyroidectomy"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8735-8616","authenticated-orcid":false,"given":"Mayas","family":"Arraf","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Ziv Medical Center Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Safia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Ziv Medical Center Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Sharabi\u2010Nov","sequence":"additional","affiliation":[{"name":"Statistics Unit, Ziv Medical Center, Safed Israel and Tel\u2010Hai Academic College, Tel\u2010Hai  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moanes","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Radiology Ziv Medical Center Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Avraham","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Ziv Medical Center Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-0695","authenticated-orcid":false,"given":"Ohad","family":"Ronen","sequence":"additional","affiliation":[{"name":"The Azrieli Faculty of Medicine Bar Ilan University Ramat Gan Israel"},{"name":"Department of Otolaryngology Head and Neck Surgery, Galilee Medical Center Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Merchavy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Ziv Medical Center Safed Israel"},{"name":"The Azrieli Faculty of Medicine Bar Ilan University Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14030919"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/aot-22-17"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104239"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13044-024-00200-z"},{"key":"e_1_2_9_6_1","first-page":"77","article-title":"Hypothyroidism after hemithyroidectomy: the incidence and risk factors","volume":"99","author":"Chotigavanich C","year":"2016","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.1.36"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2025.08.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2019.01.015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-53"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5743-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9717-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.109667"},{"key":"e_1_2_9_14_1","unstructured":"Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Accessed September 18 2025.https:\/\/pubmed.ncbi.nlm.nih.gov\/23246686\/"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"001","article-title":"Role of preoperative thyroid\u2010stimulating hormone levels in the prediction of thyroid hormone replacement after hemithyroidectomy","volume":"29","author":"Reckziegel RPF","year":"2025","journal-title":"Int Arch Otorhinolaryngol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/313971"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.1177\/01455613251333190","article-title":"Prevalence of and predictive factors for hypothyroidism following hemithyroidectomy","volume":"10","author":"Cherni F","year":"2025","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","DOI":"10.1177\/01455613251333190","article-title":"Prevalence of and predictive factors for hypothyroidism following hemithyroidectomy","volume":"10","author":"Cherni F","year":"2025","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2023.06.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ae5426"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"224","article-title":"Postparathyroidectomy transient thyrotoxicosis","volume":"75","author":"Walfish PG","year":"1992","journal-title":"J Clin Endocrinol Metab"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oto2.70239","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:12:02Z","timestamp":1787760722000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/oto2.70239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/oto2.70239"],"URL":"https:\/\/doi.org\/10.1002\/oto2.70239","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"value":"2473-974X","type":"print"},{"value":"2473-974X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70239"}}