{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:31:44Z","timestamp":1787761904179,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Given growing recognition that social determinants of health influence cancer outcomes and functional status, we sought to examine associations between social vulnerability, measured by CDC's Social Vulnerability Index (SVI), and pretreatment swallowing function, quantified by Modified Barium Swallow Impairment Profiles (MBSImP), in patients with oropharyngeal squamous cell carcinoma (OPSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Setting<\/jats:title>\n                    <jats:p>Retrospective analysis of patients at Northwestern University with pretreatment MBSImP studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MBSImP oral total (OT) and pharyngeal total (PT) scores were calculated, and SVI assigned to patient residential address at diagnosis. Associations between overall SVI, SVI subcomponents, clinical variables, and OT and PT scores were assessed using univariable and multivariable linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      149 OPSCC patients with median age 63 years; 83.9% were male, 89.9% White, and 91.9% p16+. On univariable analysis, SVI was significantly associated with higher (worse) OT (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20093.3; 95% CI: 1.8, 4.8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and PT scores (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20093.6; 95% CI: 0.75, 6.4;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.013). After multivariable adjustment, SVI remained independently associated with increased OT scores (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20092.3; 95% CI: 0.36, 4.2;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.020); PT impairment was independently predicted by tumor subsite (tonsil vs. base of tongue:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.8; 95% CI: \u22123.4, \u22120.28;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.021). All four SVI domains were significantly linked to OT in univariable models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Social vulnerability independently predicts oral\u2010phase swallowing impairment in OPSCC patients, while tumor subsite primarily determines pharyngeal swallowing impairment. These findings highlight the need to consider social determinants in pretreatment assessment, as well as further research to clarify how social determinants impact swallowing outcomes to identify effective, targeted interventions for high\u2010risk groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oto2.70242","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:39:16Z","timestamp":1777901956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship Between Social Vulnerability Index and Severity of Pretreatment Swallowing Dysfunction for Oropharyngeal Cancer Patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4489-2298","authenticated-orcid":false,"given":"Prerita","family":"Pandya","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shravan","family":"Asthana","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Soltani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Clain","sequence":"additional","affiliation":[{"name":"Roxelyn and Richard Pepper Department of Communication Sciences and Disorders Northwestern University Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten B.","family":"Burdett","sequence":"additional","affiliation":[{"name":"Division of Biostatistics &amp; Informatics, Department of Preventive Medicine Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila A.","family":"Gharzai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"},{"name":"Department of Radiation Oncology Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urjeet","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Samant","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Martin\u2010Harris","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"},{"name":"Roxelyn and Richard Pepper Department of Communication Sciences and Disorders Northwestern University Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9193-2561","authenticated-orcid":false,"given":"Katelyn O.","family":"Stepan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine, Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Social Determinants of Health \u2010 Healthy People 2030 | odphp.health.gov. 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