{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:07:51Z","timestamp":1790690871891,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To identify predictors of auditory function in treatment\u2010na\u00efve vestibular schwannomas (VS) while accounting for age\u2010related hearing loss, investigating baseline volumetrics and audiometrics in a pre\u2010intervention stereotactic radiosurgery (SRS) cohort.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n Cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Single\u2010center national SRS referral program with a prospective database.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n All consecutive patients with newly diagnosed unilateral VS and complete pre\u2010intervention imaging and audiometric data were included. High\u2010definition MRI and bone CT with co\u2010registration and fusion enabled morphometric and volumetric analysis of VS and internal auditory canal (IAC) dimensions. Univariate tests, multivariate logistic regression with interaction terms, and regularized regression identified factors associated with serviceable hearing (Gardner\u2010Robertson scores 1\u20102).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 533 patients (50.65% male, mean age 57.04 years), 72.6% had serviceable hearing. Median VS volume was 875.3\u2009mm\n 3<\/jats:sup>\n (IQR: 328.6\u20101732.5). The final multivariate model (AUC\u2009=\u20090.719) retained age (OR\u2009=\u20090.920,\n P<\/jats:italic>\n \u2009=\u2009.0144), canal filling ratio (CFR; OR\u2009=\u20090.465,\n P<\/jats:italic>\n \u2009=\u2009.0446), and a significant age\u2009\u00d7\u2009intracanalicular\u2010to\u2010total tumor volume ratio interaction (\n P<\/jats:italic>\n \u2009=\u2009.0318). Age\u2010stratified analyses revealed that the CFR\u2013hearing relationship reversed across age groups: in younger patients (<40 years), higher canal filling was associated with better hearing preservation (94% vs 73%), while this pattern reversed in older patients (>60 years). Younger patients also demonstrated greater canal dilation (\n P<\/jats:italic>\n \u2009=\u2009.002), though this lacked independent predictive value (\n P<\/jats:italic>\n \u2009=\u2009.366).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n While age dominates hearing prediction in VS, canal filling ratio significantly modifies this relationship in an age\u2010dependent manner, representing a clinically accessible imaging biomarker with age\u2010specific thresholds and effects.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/oto2.70272","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:40:23Z","timestamp":1782751223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aging and Hearing with Vestibular Schwannoma Beyond Presbycusis: A Large Cross\u2010Sectional Audiometric and Volumetric Study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-4504","authenticated-orcid":false,"given":"Sami","family":"Barrit","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery CHU Tivoli La Louvi\u00e8re Belgium"},{"name":"Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille Universit\u00e9 Marseille France"},{"name":"Research Department Science New York USA"},{"name":"Department of Neurological Surgery University of California San Francisco USA"},{"name":"Computational Precision Health University of California Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-7324","authenticated-orcid":false,"given":"Mejdeddine","family":"Al Barajraji","sequence":"additional","affiliation":[{"name":"Research Department Science New York USA"},{"name":"Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMONS) Mons Belgium"},{"name":"Department of Neurosurgery CHR Citadelle Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5521-524X","authenticated-orcid":false,"given":"Salim","family":"El Hadwe","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery CHU Tivoli La Louvi\u00e8re Belgium"},{"name":"Research Department Science New York USA"},{"name":"Department of Clinical Neurosciences University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMONS) Mons Belgium"},{"name":"Department of Surgery UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons) Mons Belgium"},{"name":"Department of Otolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil Universit\u00e9 Versailles Saint\u2010Quentin\u2010en\u2010Yvelines (Paris Saclay University) Paris France"},{"name":"Department of Otolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"},{"name":"Department of Otolaryngology Elsan Hospital of Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery CHU Tivoli La Louvi\u00e8re Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Renier","sequence":"additional","affiliation":[{"name":"Department of Radiophysics CHU UCL Namur\u2010Site H\u00f4pital Sainte\u2010Elisabeth Namur Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-1398","authenticated-orcid":false,"given":"Nicolas","family":"Massager","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery CHU Tivoli La Louvi\u00e8re Belgium"},{"name":"Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMONS) Mons Belgium"},{"name":"Faculty of Medicine Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"StatPearls","author":"Greene J","year":"2025"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"5","article-title":"Stereotactic radiosurgery for vestibular schwannoma: International Stereotactic Radiosurgery Society (ISRS) Practice Guideline","volume":"5","author":"Tsao MN","year":"2017","journal-title":"J 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