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Treatments included nimodipine (n\u2009=\u20096), pentoxifylline (n\u2009=\u20091), co\u2010enzyme Q10 (n\u2009=\u20091), and extracellular vesicles (n\u2009=\u20091). All studies used HB score, and recovery was defined as HB score \u22643. Recovery was observed in 94% (95% CI:[90%, 97%]) of patients treated with nimodipine and 84% (95% CI: [70%, 97%]) of control patients; this was not statistically significant (OR 2.26, 95% CI: [0.97, 5.26]). Nimodipine significantly decreased HB score by 1.66 (95% CI: [0.81, 2.52]) before and after treatment. Pentoxifylline and extracellular vesicles demonstrated some efficacy, while co\u2010enzyme Q10 was not efficacious.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nimodipine improved HB score but was not significantly associated with recovery to HB score \u22643 compared to controls. Pentoxifylline and extracellular vesicles may have some efficacy, but co\u2010enzyme Q10 is not effective. Further research is required to uncover additional treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oto2.70275","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:37:48Z","timestamp":1782747468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging Medications in Facial Nerve Recovery: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4053-4990","authenticated-orcid":false,"given":"Kimberly","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-6335","authenticated-orcid":false,"given":"Bao Y.","family":"Sciscent","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2013Head and Neck Surgery at the University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9769-0903","authenticated-orcid":false,"given":"Andreacarola","family":"Urso","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-1097","authenticated-orcid":false,"given":"Neerav","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-5059","authenticated-orcid":false,"given":"Jessyka G.","family":"Lighthall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WalkerNR MistryRK MazzoniT.Facial Nerve Palsy;2024."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813505967"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43163-023-00450-y"},{"issue":"31","key":"e_1_2_8_5_1","first-page":"S1","article-title":"Best practices in facial nerve monitoring","volume":"131","author":"Kartush JM","year":"2021","journal-title":"Laryngoscope"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.1192"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000231266.84401.55"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318254b08d"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00026"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.3049"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071678"},{"key":"e_1_2_8_13_1","unstructured":"Centre for Evidence\u2010Based Medicine (CEBM). 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