{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:53:22Z","timestamp":1791896002599,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["5S21MD000242"],"award-info":[{"award-number":["5S21MD000242"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["5S21MD000138"],"award-info":[{"award-number":["5S21MD000138"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence and predictors of thyroid gland invasion in Hispanic patients with laryngeal squamous cell carcinoma undergoing total laryngectomy and to assess thyroidectomy\u2010associated comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cross\u2010sectional review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University District Hospital, Puerto Rico Medical Center, San Juan, PR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Records of adults with laryngeal squamous cell carcinoma who underwent total laryngectomy from 2009 to 2022 were reviewed. Tumor characteristics were correlated with histopathologic thyroid gland invasion, and postoperative hypocalcemia was documented. Categorical variables were compared using Fisher's exact or Pearson's chi\u2010square tests, with effect size reported by Cram\u00e9r's\n                      <jats:italic>V<\/jats:italic>\n                      ; continuous variables were analyzed with the Wilcoxon\u2010Mann\u2010Whitney test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 105 patients, 8 (7.6%) had thyroid gland invasion. Tumors with invasion were larger (5.0\u2009\u00b1\u20091.3 vs 3.3\u2009\u00b1\u20091.4\u2009cm;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.003) and were associated with thyroid cartilage invasion (100% vs 54.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.020). Patients with invasion underwent total thyroidectomy more often (75.0% vs 28.9%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.013). Postoperative hypocalcemia occurred in 41.9% (44\/105) of patients overall and was more frequent after total than after partial thyroidectomy (79.4% vs 23.9%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Intravenous calcium replacement was required in 19.0% (20\/105) of patients, more often after total thyroidectomy (47.1% vs 5.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thyroid gland invasion was uncommon but associated with larger tumors and thyroid cartilage invasion. Total thyroidectomy carried a higher risk and greater severity of hypocalcemia. These findings support selective thyroid management during total laryngectomy and provide evidence from an underrepresented Hispanic population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oto2.70312","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:28:33Z","timestamp":1791894513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thyroid Involvement in Laryngeal Squamous Cell Carcinoma\u2014Should it be Spared?"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5921-4675","authenticated-orcid":false,"given":"Francisco J.","family":"Garrat\u00f3n\u2010Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery University of Puerto Rico, School of Medicine San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Bonafont\u2010Reyes","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Puerto Rico, School of Medicine San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7394-5737","authenticated-orcid":false,"given":"Javier A.","family":"Vil\u00e1 Ortiz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery University of Puerto Rico, School of Medicine San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bur\u00e9s\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery University of Puerto Rico, School of Medicine San Juan Puerto Rico USA"},{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Massachusetts Eye and Ear Infirmary, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Corona\u2010Ru\u00edz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery University of Puerto Rico, School of Medicine San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeamarie","family":"Pascual\u2010Marrero","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery University of Puerto Rico, School of Medicine San Juan Puerto Rico USA"},{"name":"Department of Otolaryngology Veteran's Affairs Medical Center San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"463","article-title":"Conservation surgery of cancer of the larynx","volume":"65","author":"Ogura JH","year":"1955","journal-title":"Laryngoscope"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"303","article-title":"The thyroid gland in the management of laryngopharyngeal cancer","volume":"97","author":"Harrison DFN","year":"1973","journal-title":"Arch Otolaryngol"},{"key":"e_1_2_9_4_1","unstructured":"National Comprehensive Cancer Network (NCCN). Head and Neck Cancers Version 1.2016. NCCN Clinical Practice Guidelines in Oncology. 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A randomized controlled trial","volume":"74","author":"El\u2010Sebai Ali M","year":"2022","journal-title":"Ann Med Surg"},{"key":"e_1_2_9_12_1","volume-title":"AJCC Cancer Staging Manual","author":"Amin MB","year":"2017"},{"issue":"10","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1007\/s00405-015-3635-4","article-title":"Preoperative assessment and classification of benign laryngotracheal stenosis: a consensus paper of the European Laryngological Society","volume":"272","author":"Monnier P","year":"2015","journal-title":"Eur Arch Otrhinolaryngol"},{"issue":"8","key":"e_1_2_9_14_1","first-page":"3947","article-title":"Thyroid gland invasion in total laryngectomy: a systematic review and meta\u2010analysis","volume":"279","author":"Xie J","year":"2022","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1186\/s12885-020-07205-5","article-title":"Is thyroid excision mandatory with laryngectomy in carcinoma larynx?","volume":"20","author":"Baghel SS","year":"2020","journal-title":"BMC Cancer"},{"issue":"9","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1288\/00005537-199109000-00003","article-title":"The intraoperative management of the thyroid gland during laryngectomy","volume":"101","author":"Brennan JA","year":"1991","journal-title":"Laryngoscope"},{"issue":"3","key":"e_1_2_9_17_1","first-page":"1205","article-title":"Predictors of thyroid gland invasion in advanced laryngeal carcinoma: when is an elective thyroidectomy indicated?","volume":"282","author":"Horakova Z","year":"2025","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"3","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/hed.20693","article-title":"Thyroid dysfunction in laryngectomees 10 years after treatment","volume":"30","author":"Ho ACW","year":"2008","journal-title":"Head Neck"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oto2.70312","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oto2.70312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:28:36Z","timestamp":1791894516000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/oto2.70312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/oto2.70312"],"URL":"https:\/\/doi.org\/10.1002\/oto2.70312","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"value":"2473-974X","type":"print"},{"value":"2473-974X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70312"}}