{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:33:41Z","timestamp":1784291621090,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effectiveness between cyanoacrylate tissue adhesives (CTAs) and sutures for skin closure on the face and neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Embase, Medline, Scopus, Central, Web of Science.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Randomized controlled trials comparing CTAs versus sutures for skin closure on the face and neck were included. Primary outcomes were cosmetic outcomes. Secondary outcomes were scar depth, scar width, pain, closure time, cost, and adverse events. Subgroup analyses were performed by wound locations, type of CTAs, type of sutures, age groups, and type of wounds. Physicians and patients evaluated the cosmetic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen studies (1020 patients) were included. CTAs offered better cosmetic outcomes by Wound Registry Scale at \u22641 month (physician: mean difference [MD]: \u22121.50, 95% confidence interval, CI: \u22122.42 to \u22120.58). The cosmetic outcomes assessed by Visual Analog Scale were comparable at &gt;1 to \u22643 months (physicians: standard mean difference [SMD], \u22120.01, 95% CI, \u22120.25 to 0.23, patients: SMD, \u22120.02, 95% CI, \u22120.84 to 0.79). The cosmetic outcomes by the Patient and Observer Scar Assessment Scale favored sutures at &gt;3 to 12 months (physician: MD 4.26, 95% CI, 2.02\u20106.50). Subgroup analyses revealed no differences. CTAs offered less scar depth, scar width, pain, closure time, and total cost of closure. Adverse events were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the wound healing process, the cosmetic outcomes exhibited a favorable inclination toward CTAs at &lt;1 month while demonstrating comparable results between CTAs and sutures at &gt;1 to \u22643 months. Subsequently, sutures exhibited superior cosmetic outcomes compared to CTAs at &gt;3 to 12 months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.73","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:35:35Z","timestamp":1694165735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cyanoacrylate Tissue Adhesives Compared With Sutures on Facial and Neck Wounds: A Meta\u2010analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-845X","authenticated-orcid":false,"given":"Prapitphan","family":"Charoenlux","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine, Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-7573","authenticated-orcid":false,"given":"Nattawan","family":"Utoomprurkporn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine, Chulalongkorn University Bangkok Thailand"},{"name":"Faculty of Brain Science, UCL Ear Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-7638","authenticated-orcid":false,"given":"Kachorn","family":"Seresirikachorn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine, Chulalongkorn University Bangkok Thailand"},{"name":"Endoscopic Nasal and Sinus Surgery Excellence Center King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.12.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12040939"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00059-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.101049"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110796"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2007.05.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.19.5.382"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001576"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.013"},{"key":"e_1_2_9_11_1","volume-title":"StatPearls [Internet]","author":"Perera AGN","year":"2023"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000600008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00798"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198402000-00012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2003.11.017"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-014-1056-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.64129"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1996.tb03440.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.9.1177"},{"key":"e_1_2_9_20_1","first-page":"216","article-title":"A prospective randomised controlled trial of octylcyanoacrylate tissue adhesive and standard suture for wound closure following breast surgery","volume":"22","author":"Chen CT","year":"2016","journal-title":"Hong Kong Med J"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2021.08.015"},{"key":"e_1_2_9_22_1","article-title":"Tissue adhesives for traumatic lacerations in children and adults","volume":"2002","author":"Farion K","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_24_1","volume-title":"Cochrane handbook for systematic reviews of interventions version 5.2.0 (updated June 2017)","author":"Higgins JPT","year":"2017"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0259-8"},{"key":"e_1_2_9_27_1","unstructured":"The Cochrane Collaboration.RevMan Whenever Its Output is Used: Review Manager (RevMan)[Computer Program]. 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