{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:35:49Z","timestamp":1791416149171,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the efficacy of posterior nasal nerve (PNN) cryoablation for improving the symptoms of chronic rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A private practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study evaluated medication usage and adverse effects of in\u2010office PNN cryoablation with a handheld device in patients\u2009&gt;\u200918 years with chronic (&gt;6 months) allergic or nonallergic rhinitis for whom medical management failed. The total nasal symptom score (TNSS) and mini rhinoconjunctivitis quality of life questionnaire (mRQLQ) scores were compared before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 127 patients with a mean age of 52.4\u2009\u00b1\u200916.9 years; 60.6% of patients were female and 49.6% had allergic rhinitis. Mean symptom scores decreased from 5.94 (95% confidence interval [CI], 5.51\u20106.43) to 3.44 (95% CI, 2.97\u20103.81, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) after the procedure, with clinically important decreases in 75 (59.1%) patients. For patients with baseline TNSS values of \u22654, 63.5% (66\/104) had a clinically important decrease, whereas only 39.1% (9\/23) of those with the lower baseline did (<jats:italic>P<\/jats:italic>\u2009=\u2009.04). Mean mRQLQ scores also decreased from 2.51 (95% CI, 2.29\u20102.72) to 1.28 (95% CI, 1.20\u20101.47, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) after the procedure. Seventy\u2010eight of 273 (28.6%) medications were discontinued after the procedure. Adverse effects occurred in 18.1% (23\/127) of patients with headache as the most common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PNN\u00a0cryoablation improves nasal symptoms and quality of life in patients with chronic rhinitis. Patients with a higher baseline TNSS are more likely to experience significant symptomatic improvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oto2.77","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:34:18Z","timestamp":1697513658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Improvement in Nasal Symptoms of Chronic Rhinitis after Cryoablation of the Posterior Nasal Nerve"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4690-151X","authenticated-orcid":false,"given":"Mattie","family":"Rosi\u2010Schumacher","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-5426","authenticated-orcid":false,"given":"Adam","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Young","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat, PLLC Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143183"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12130"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-7-12"},{"key":"e_1_2_9_5_1","volume-title":"The WAO White Book on Allergy (Update)","author":"Pawankar R","year":"2013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3603"},{"issue":"1","key":"e_1_2_9_8_1","first-page":"22","article-title":"A cost of illness study of allergic rhinitis in the United States","volume":"99","author":"Malone DC","year":"1997","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"373","article-title":"The cost of productivity losses associated with allergic rhinitis","volume":"6","author":"Crystal\u2010Peters J","year":"2000","journal-title":"Am J Manag Care"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22748"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.10.014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X41408"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60408-5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60663-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100057716"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487209138970"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0093-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.831478"},{"key":"e_1_2_9_19_1","unstructured":"ClariFix. 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