{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:23:57Z","timestamp":1776950637163,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["U10\u2010EY08893"],"award-info":[{"award-number":["U10\u2010EY08893"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R21\u2010EY12273"],"award-info":[{"award-number":["R21\u2010EY12273"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R21\u2010EY035270"],"award-info":[{"award-number":["R21\u2010EY035270"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020485","name":"CooperVision","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OVS"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The second principal point (H\u2032) of the eye can be used to estimate the diopters of change in refractive error that result from each millimeter of axial elongation. Calculating the location of H\u2032 requires data from phakometry, a technique not included in most myopia control clinical trials. Previous estimates have ranged from 1.602\u00a0mm (Gullstrand) to 2.1\u00a0mm. The purpose of this analysis is to develop a method for estimating the location of H\u2032 in children using more readily available biometric data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Children (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04913) from the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) study provided the necessary biometric data to find the location of H\u2032. Crystalline lens power was also estimated using Bennett's method. A generalized linear model was used to create an equation that could estimate the location of H\u2032 without phakometry data which was then validated against the CLEERE values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average (\u00b1SD) position of H\u2032 in CLEERE children was 1.90\u00a0\u00b1\u00a00.15\u00a0mm posterior to the cornea. Multivariate modeling resulted in the following equation:  (adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.60). The position of H\u2032 using this model agreed well with the position calculated using the CLEERE complete set of biometric data, with an average difference (\u00b1SD) of 0.003\u00a0\u00b1\u00a00.094\u00a0mm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Estimating the location of H\u2032 does not require phakometry. The position of H\u2032 was intermediate between the classic Gullstrand value and the value previously estimated for children. This method could be used with patients or in clinical trials to gauge the effects and effectiveness of myopia control by estimating the fraction of inhibition of eye elongation that comprises compensated elongation compared to uncompensated elongation, setting targets for slowing eye growth to the point of no net myopia progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ovs2.70002","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:00:22Z","timestamp":1773892822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Compensated versus uncompensated millimeters during myopia progression: Estimating H\u2032 in children"],"prefix":"10.1002","volume":"103","author":[{"given":"Derik M.","family":"Holmberg","sequence":"first","affiliation":[{"name":"The Ohio State University College of Optometry  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald O.","family":"Mutti","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Optometry  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"CLEERE Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.03.012"},{"key":"e_1_2_8_3_1","first-page":"3625","article-title":"Myopia and incident cataract and cataract surgery: the Blue Mountains eye study","volume":"43","author":"Younan C","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_8_4_1","first-page":"310","article-title":"The relationship between refractive errors and retinal detachment\u2014analysis of 1,166 retinal detachment cases","volume":"32","author":"Ogawa 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