{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:28:13Z","timestamp":1787246893416,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OVS"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effectiveness of low\u2010dose atropine in slowing myopic progression in children with inherited retinal diseases (IRDs) and myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective study of children with IRDs, comparing myopia progression between those who received atropine drops and those who did not was conducted. Annual myopia progression rates were estimated from longitudinal spherical equivalent measurements. Progression was compared between groups using the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test and within groups using the Wilcoxon signed\u2010rank test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 27 children (262 refractive examinations) with IRDs and myopia were included (atropine group: 12 children and control group: 15 children).\n                      <jats:italic>TRPM1<\/jats:italic>\n                      was the most common gene in both groups. Treatment with atropine was initiated at a mean age of 6.4\u00a0years. In the atropine group, mean annual myopic progression decreased from \u22121.01\u00a0D\/year before treatment to \u22120.28\u00a0D\/year after treatment initiation. In the control group, mean annual myopic progression decreased from \u22120.81\u00a0D\/year before 6\u00a0years of age to \u22120.45\u00a0D\/year thereafter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In children with IRDs, low\u2010dose atropine treatment did not significantly alter myopia progression once age\u2010related effects were accounted for. Early intervention might be required, suggesting the need for future studies exploring earlier treatment and alternative optical strategies for myopia management in this vulnerable pediatric population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ovs2.70053","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:21:18Z","timestamp":1778037678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the role of low\u2010dose atropine in myopia management in children with inherited retinal diseases"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3132-8953","authenticated-orcid":false,"given":"Rotem","family":"Azmon","sequence":"first","affiliation":[{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Kreindler","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Ezra Kahtan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Knisbacher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hadassah Medical Center. Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Mysler","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hadassah Medical Center. Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Ehrenberg","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shneider Children's Medical Center  Petach Tikva Israel"},{"name":"Grey Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hendler","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hadassah Medical Center. 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