{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:28:13Z","timestamp":1787246893429,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OVS"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Regional patterns of visual field (VF) loss may affect vision\u2010related quality of life (QoL) differently in people with glaucoma; yet evidence across studies remains inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify and evaluate studies comparing vision\u2010related QoL, measured by the National Eye Institute Visual Function Questionnaire (NEI\u2010VFQ\u201025), with specific regions of VF loss in glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>MEDLINE, EMBASE, CINAHL, PsycINFO, and AMED were systematically searched from inception to April 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Eligibility Criteria<\/jats:title>\n                    <jats:p>Eligible studies included adults with glaucoma that examined regional VF loss (e.g.,\u00a0central vs. peripheral, hemifield, or cluster analyses) and reported NEI\u2010VFQ\u201025 outcomes. Studies using only global VF indices were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Appraisal and Synthesis Methods<\/jats:title>\n                    <jats:p>Two reviewers independently screened studies, extracted data, and assessed methodological quality using the Joanna Briggs Institute tools. Due to heterogeneity in VF metrics and NEI\u2010VFQ\u201025 scoring approaches, the findings were synthesized narratively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02626 participants) met the inclusion criteria. Most cohorts were relatively young (mean age mid\u201060s) with mild\u2013moderate glaucoma; only two included participants with advanced loss. Despite methodological variation, a consistent pattern emerged: central and inferior VF loss were most strongly associated with poorer QoL, whereas superior and peripheral loss showed weaker or domain\u2010specific effects. Associations were generally stronger when using better\u2010eye or integrated VF measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The evidence base is limited by few studies, small sample sizes, predominance of mild disease, and variability in both VF and NEI\u2010VFQ\u201025 methodologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications of Key Findings<\/jats:title>\n                    <jats:p>Central and inferior VF loss appear most closely linked to reduced QoL; however, conclusions are constrained by the limited number and methodological heterogeneity of available studies. Larger, standardized investigations across disease stages are needed to clarify these relationships and guide patient\u2010centered care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO CRD420251169334.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ovs2.70055","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:24:42Z","timestamp":1778037882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Location of visual field defects and their impact on vision\u2010related quality of life in glaucoma: A systematic review"],"prefix":"10.1002","volume":"103","author":[{"given":"Bethany E.","family":"Higgins","sequence":"first","affiliation":[{"name":"Optometry and Visual Sciences City St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-3902","authenticated-orcid":false,"given":"David P.","family":"Crabb","sequence":"additional","affiliation":[{"name":"Optometry and Visual Sciences City St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Optometry and Visual Sciences City St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart K.","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Devers Eye Institute Legacy Health  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2014.3192"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0B013E32832401A9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAOPHTHALMOL.2013.2602"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.08.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/EYE.2015.244"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.11.1496"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHOPHT.119.7.1050"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3310\/HTA25720"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAOPHTHALMOL.2024.3282"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHOPHT.1997.01100150779014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/AOS.12839"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1621640"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903000103"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161\u20106420(00)00284\u20100"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31822f4d6a"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475\u20101313.2010.00811.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10384\u2010014\u20100359\u20108"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2013.02.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009710"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.02.031"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000702"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.12.9"},{"key":"e_1_2_9_24_1","unstructured":"Innovation VH.Covidence systematic review software.2019. 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