{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:46:32Z","timestamp":1782200792404,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["T35 EY00715"],"award-info":[{"award-number":["T35 EY00715"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001070"],"award-info":[{"award-number":["UL1TR001070"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000121","name":"Division of Mathematical Sciences","doi-asserted-by":"publisher","award":["DMS 2208373"],"award-info":[{"award-number":["DMS 2208373"]}],"id":[{"id":"10.13039\/100000121","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OVS"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To test the hypothesis that a larger, latanoprost\u2010induced intraocular pressure (IOP) reduction is associated with a thicker ciliary muscle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a031) were healthy with the following details: mean\u00a0\u00b1\u00a0SD age 24.8\u00a0\u00b1\u00a03.3\u00a0years. The ciliary muscle was imaged with anterior segment optical coherence tomography and Goldmann IOP was measured at baseline and 12\u201318\u00a0h after latanoprost instillation. Linear regression models of baseline IOP and IOP reduction as predicted by baseline ciliary muscle thickness were performed. Partial correlation coefficients were calculated for model predictor variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean\u00a0\u00b1\u00a0SD latanoprost\u2010induced IOP reduction was \u22122.6\u00a0\u00b1\u00a02.1\u00a0mmHg (\n                      <jats:italic>t<\/jats:italic>\n                      \u00a0=\u00a0\u22127.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). A larger reduction in IOP was significantly associated with thicker baseline maximum ciliary muscle thickness (CMTMAX) after controlling for age and baseline IOP (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.37; CMTMAX: \u22120.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01; age: 0.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.08; baseline IOP: \u22120.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003), and was also significantly associated with thicker baseline ciliary muscle thickness 1\u00a0mm posterior to the scleral spur (CMT1) after controlling for age and baseline IOP (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.44; CMT1: \u22120.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002; age: 0.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.06; baseline IOP: \u22120.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0008). Partial correlation coefficients between IOP reduction and baseline CMTMAX or CMT1 were \u22120.47 and \u22120.56, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thicker baseline CMTMAX\/CMT1 was associated with larger latanoprost\u2010induced IOP reductions and lower baseline IOP. Future studies should determine the clinical usefulness of ciliary muscle dimensions as a predictor of the response to latanoprost in glaucoma patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ovs2.70076","type":"journal-article","created":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T01:44:00Z","timestamp":1782006240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ciliary muscle thickness and intraocular pressure before and after latanoprost"],"prefix":"10.1002","volume":"103","author":[{"given":"Emily","family":"Slywka","sequence":"first","affiliation":[{"name":"The Ohio State University College of Optometry  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu\u2010Yen","family":"Kao","sequence":"additional","affiliation":[{"name":"Claremont McKenna College  Claremont California 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